Atelocollagen Injection Improves Tendon Integrity in Partial-Thickness Rotator Cuff Tears: A Prospective Comparative Study

Orthopaedic Journal of Sports Medicine
Jong-Ho KimYang-Soo Kim

Abstract

Ongoing controversy surrounds the best treatment modality for partial-thickness rotator cuff tears. To investigate the effects of atelocollagen injection in patients with small, symptomatic, intratendinous rotator cuff tears. Randomized controlled trial; Level of evidence, 1. From January 2014 to December 2017, 94 patients who had small, symptomatic, intratendinous rotator cuff tears were enrolled and randomly allocated to 1 of 3 groups: intratendinous injection with 0.5 mL of type I atelocollagen (group 1, n = 32), intratendinous injection with 1 mL of type I atelocollagen (group 2, n = 30), and no injection of type I atelocollagen (group 3, n = 32). American Shoulder and Elbow Surgeons score, Constant Shoulder Score, visual analog scale pain score, and range of motion were evaluated before injection; at 3, 6, and 12 months after injection; and at final follow-up. Magnetic resonance imaging (MRI) was performed at least 6 months after injection to evaluate rotator cuff integrity. Demographic data did not differ significantly among the 3 groups before injection (P > .05). The mean follow-up period was 24.7 months. The functional and pain scores in groups 1 and 2 were significantly improved at final follow-up (P < .05). No signif...Continue Reading

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