PMID: 7332738Nov 1, 1981

Atenolol in the treatment of pregnancy-induced hypertension

British Journal of Clinical Pharmacology
K J ThorleyJ M Cruickshank

Abstract

1 The pharmacological properties of atenolol suggest its possible usefulness in pregnancy-induced hypertension. The pharmacokinetics of atenolol in the pregnant woman, concentrations in cord blood, and its effects on maternal blood pressure and the foetus, are evaluated. 2 We studied 13 pregnant women with hypertension, most of them uncontrolled on methyldopa. Whole blood concentrations and urinary excretion of the drug were measured over 24 h following a 100 mg dose. Effects on maternal blood pressure, pulse rate and foetal heart rate and cardiotocograph were compared for the 4 days before treatment and the first 4 days of treatment. The birth weights and Apgar scores of the babies were recorded. 2 The pharmacokinetics of atenolol (plasma half-life of about 8 h) in pregnant women do not differ from the findings in the non-pregnant. The levels of atenolol in the cord blood were confirmed as approximately equal to those in the maternal blood. 4 In the ten women in whom blood pressure was assessed a small significant fall in blood pressure was observed. 5 A 5% mean fall in foetal heart rate resulted but in one case was a rate below 120 beats/min recorded. There was no evidence of depression of the stress response of the foetal he...Continue Reading

References

Jan 1, 1976·Drugs·G Johnsson, C G Regårdh
Nov 1, 1976·Clinical Pharmacology and Therapeutics·H C BrownR G Shanks
Jan 8, 1977·British Medical Journal·J WebsterN P Barker
Jan 1, 1979·Acta Obstetricia Et Gynecologica Scandinavica·N O LunellH Aström
Jun 1, 1975·The Journal of Pharmacy and Pharmacology·B Scales, P B Copsey
Apr 21, 1979·British Medical Journal·H J Waal-Manning, P Bolli
Mar 3, 1979·British Medical Journal·R Wilkinson
Oct 1, 1979·British Journal of Clinical Pharmacology·M F O'HareD G McDevitt
May 1, 1978·British Journal of Obstetrics and Gynaecology·J F Pearson, J B Weaver
Jun 1, 1978·British Journal of Obstetrics and Gynaecology·H E EliahouD M Serr
Sep 1, 1978·British Journal of Obstetrics and Gynaecology·B A LiebermanE Belsey
Nov 16, 1978·European Journal of Clinical Pharmacology·A MelanderN O Sjöberg
Nov 1, 1978·British Journal of Clinical Pharmacology·H E BarberJ M Swann
Nov 1, 1977·The Journal of Pediatrics·A Habib, J S McCarthy
Jun 1, 1975·The Journal of Pediatrics·G R GladstoneW M Gersony
Jan 1, 1973·British Journal of Pharmacology·J F TrueloveR F Willes
Apr 1, 1974·Clinical Pediatrics·H Zellweger
Jun 1, 1981·British Journal of Clinical Pharmacology·G Neil-DwyerJ M Cruickshank
Apr 1, 1979·British Journal of Clinical Pharmacology·G D Lamming, E B Symonds

Citations

Jan 1, 1983·Pharmacology & Therapeutics·M J Kendall, L Beeley
Apr 6, 2002·Reproductive Toxicology·Sonia A Tabacova, Carole A Kimmel
Jul 1, 1997·Reproductive Toxicology·D SatgéE Robert
Apr 1, 1982·The New England Journal of Medicine
Sep 16, 1982·The New England Journal of Medicine·W F Lubbe
Apr 1, 1990·British Journal of Clinical Pharmacology·I SchabortD M Pierce
Oct 16, 1982·British Medical Journal·K J Thorley
Dec 17, 2004·Journal of Clinical Pharmacology·Mary F HebertThomas R Easterling
Sep 24, 2005·Clinical Pharmacokinetics·Gail D Anderson
Apr 24, 2009·Clinical Pharmacokinetics·Gail D Anderson, Darcy B Carr
Nov 28, 2006·Expert Opinion on Drug Metabolism & Toxicology·Gail D Anderson
May 1, 1991·Drug and Alcohol Dependence·V Morrison
Apr 1, 1992·American Heart Journal·M BrodskyM Sada
Nov 1, 1983·British Journal of Clinical Pharmacology·P C RubinJ L Reid
Aug 1, 1982·British Journal of Clinical Pharmacology·P C RubinJ L Reid
Jan 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·K WichmanB E Karlberg
Mar 1, 1991·British Journal of Obstetrics and Gynaecology·S Blake, D MacDonald

Related Concepts

Tenormin
Fetal Structures
Hypertensive Disease
Pregnancy Complications, Cardiovascular
Propanolamines

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