Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus

British Journal of Pharmacology
Morgayn I ReadIvan A Sammut

Abstract

Status epilepticus is increasingly associated with cardiac injury in both clinical and animal studies. The current study examined ECG activity for up to 48 h following kainic acid (KA) seizure induction and compared the potential of atenolol and clonidine to attenuate this cardiac pathology. Sprague-Dawley rats (male, 300-350 g) were implanted with ECG and electrocorticogram electrodes to allow simultaneous telemetric recordings of cardiac and cortical responses during and after KA-induced seizures. Animals were randomized into saline controls, and saline vehicle-, clonidine- or atenolol-pretreated KA groups. KA administration in the saline-pretreated group produced an immediate bradycardic response (maximal decrease of 28 ± 6%), coinciding with low-level seizure activity. As high-level seizure behaviours and EEG spiking increased, tachycardia also developed, with a maximum heart rate increase of 38 ± 7% coinciding with QTc prolongation and T wave elevation. Both clonidine and atenolol pretreatment attenuated seizure activity and reduced KA-induced changes in heart rate, QTc interval and T wave amplitude observed during both bradycardic and tachycardic phases in saline-pretreated KA animals. Clonidine, however, failed to reduce...Continue Reading

References

May 17, 1978·European Journal of Clinical Pharmacology·A KeränenJ Taskinen
Sep 1, 1992·Journal of the Neurological Sciences·M KobariH Takeda
Jun 4, 1987·European Journal of Pharmacology·M OhnoS Ueki
Oct 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·Z Kleinrok, L Turski
Jan 1, 1981·Medicinal Research Reviews·L Patel, P Turner
Mar 2, 1995·Journal of the Autonomic Nervous System·K MatsukawaJ H Mitchell
Jan 1, 1993·Epilepsy Research·J G BoggsR J DeLorenzo
Jun 17, 1998·Archives of Neurology·B H NatelsonR Turizo
Aug 14, 1998·General Pharmacology·M Z Dernovsek, D Sket
Nov 24, 1998·Circulation·D P Zipes, H J Wellens
Feb 6, 1999·Journal of the American College of Cardiology·E R AzevedoJ D Parker
Apr 3, 1999·Annals of Internal Medicine·E R LocatelliS J Potolicchio
Jun 4, 1999·Brain : a Journal of Neurology·F ProviniP Montagna
Jun 18, 1999·Cardiovascular Drugs and Therapy·C Smith, M Teitler
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R Kloster, T Engelskjøn
May 19, 2000·International Journal of Cardiology·Y Zhang, Z Cheng
Nov 14, 2000·Trends in Neurosciences·Y Ben-Ari, R Cossart
Sep 29, 2001·British Journal of Anaesthesia·J E HallT J Ebert
Nov 30, 2002·Epilepsy Research·Christian OpherkLawrence J Hirsch
Mar 1, 2003·Epilepsy & Behavior : E&B·Matthew R. Sarkisian
Mar 5, 2003·Epilepsia·Fritz LeutmezerChristoph Baumgartner
May 12, 2004·Epilepsy Research·Claudia Stöllberger, Josef Finsterer
Nov 25, 2004·Epilepsy Currents·Orrin Devinsky
Sep 24, 2005·BMJ : British Medical Journal·Matthew Walker
Oct 22, 2005·Annals of Neurology·Edward M MannoEelco F M Wijdicks
Jan 6, 2006·Epilepsia·Giancarlo LogroscinoPierre Jallon
Mar 28, 2006·Journal of Neuroscience Methods·Philip WilliamsF Edward Dudek
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Jan 22, 2008·Pediatric Neurology·Frans J M FeronJohan S H Vles
May 14, 2008·Journal of Hypertension·Emil ToaderLuc Quintin
Aug 30, 2008·Epilepsia·Cameron S MetcalfSteven L Bealer
Jun 9, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Anthony J OconJulian M Stewart

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