Atezolizumab for the treatment of colorectal cancer: the latest evidence and clinical potential

Expert Opinion on Biological Therapy
Gonzalo Tapia Rico, Timothy J Price

Abstract

Atezolizumab is a fully humanized, engineered monoclonal antibody (MAb) of IgG1 isotype that specifically targets programmed death ligand 1 (PD-L1), a key molecule in the cancer-immunity pathway. Atezolizumab is currently approved for the treatment of metastatic non-small-cell lung cancer (NSCLC) and advanced urothelial carcinomas. Areas covered: In this review, we will present the available (early phase clinical trials) data supporting the efficacy of atezolizumab for the treatment of metastatic colorectal cancer (mCRC). We will also provide an update on the ongoing/future clinical trials evaluating the role of atezolizumab for the treatment of colorectal cancer (CRC) in different settings (alone or in combination with other checkpoint inhibitors and/or targeted therapies). So far, a small subgroup of mCRC (those with deficiency in mismatch repair (dMMR) - also known as microsatellite instability high (MSI-H) - appear to benefit significantly from checkpoint inhibitors. As expected, further research is needed to develop biomarkers, effective therapeutic strategies and novel combinations to overcome immune escape resistance and achieve better clinical responses with minimal toxicities. Expert opinion: Interim analyses from ongo...Continue Reading

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Oct 3, 2019·Cancers·Theodoulakis ChristofiApostolos Zaravinos
Oct 24, 2019·Expert Opinion on Biological Therapy·Alexandre A Jácome, Cathy Eng
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Dec 20, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qinlian JiaoYun-Shan Wang
Apr 14, 2021·Seminars in Cancer Biology·Pietro AndreiAlberto Bardelli

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