PMID: 16628010Apr 22, 2006Paper

ATF3 regulates the stability of p53: a link to cancer

Cell Cycle
Chunhong Yan, Douglas D Boyd

Abstract

ATF3 is a member of the ATF/CREB family of transcription factors involved in the cellular response to a large variety of stresses including DNA damage. However, neither the signaling leading to nor the biological significance of its induction upon stress is well understood. Although it is generally believed that ATF3 exerts its function in the stress response by regulating transcription, to date, only a limited number of target genes have been identified. We recently reported that ATF3 interacts with the tumor suppressor p53 to increase its stability in the genotoxic response. While providing the cell a general means of responding to diverse adverse environment cues, this mechanism confers ATF3 with an ability to promote tumor suppressor functions. Conversely, dysfunction of ATF3 impairs the p53-mediated cellular response to DNA damage, allowing cells to be readily transformed by oncogenes. Consistent with this notion is the observation of downregulated ATF3 expression in most human cancers. Therefore, our findings indicate that ATF3 intersects with p53-associated pathways ensuring genomic integrity. The ability of ATF3 to stabilize p53-induced pathways thus represents a means of effectively countering DNA damage caused by envi...Continue Reading

Citations

Oct 25, 2011·Cancer Metastasis Reviews·Xingya WangThomas Eling
Feb 20, 2010·The Journal of Biological Chemistry·Hongbo WangChunhong Yan
Jul 2, 2010·The Journal of Biological Chemistry·Pingli MoChunhong Yan
Apr 10, 2012·Nutrition and Cancer·Nichelle C Whitlock, Seung Joon Baek
Dec 17, 2008·Photochemistry and Photobiology·Brian P PollackJeremy M Boss
Sep 20, 2008·BMC Neuroscience·Harukazu Saito, Lars B Dahlin
Feb 19, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alina AguirreGuillermo M Albaiceta
Jun 17, 2016·Molecular & Cellular Oncology·Ziyan Wang, Chunhong Yan
Jul 7, 2012·Journal of Cutaneous Pathology·Crystal L RoseMichael T Tetzlaff
Aug 15, 2017·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Ilona Schoen, Sabine Koitzsch
Feb 10, 2018·Scientific Reports·Zsuzsanna UjfaludiImre M Boros
May 31, 2008·Cell Death and Differentiation·L TurchiT Virolle
Feb 17, 2009·Cell Death and Differentiation·L TurchiT Virolle
Feb 21, 2014·The Journal of Biological Chemistry·Saisai WeiChunhong Yan
Apr 21, 2017·Oncotarget·Richard MorganHardev S Pandha
Nov 17, 2016·BMC Systems Biology·Andrew T McKenzieBin Zhang
Nov 1, 2018·Journal of Experimental & Clinical Cancer Research : CR·Cong ChenJinjun Li
Dec 5, 2019·Cell Death and Differentiation·Xingyao LiChunhong Yan
Oct 31, 2019·Biological Reviews of the Cambridge Philosophical Society·Goodwin G Jinesh, Andrew S Brohl
Mar 20, 2016·The Journal of Biological Chemistry·Hongmei CuiChunhong Yan
Jun 19, 2007·Cancer Research·Richard MorganHardev S Pandha
Dec 11, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tingjian ZuGeorge F Murphy
Feb 22, 2021·Progress in Biophysics and Molecular Biology·Ruifang SunDongmei Diao
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