ATF7 mediates TNF-α-induced telomere shortening

Nucleic Acids Research
Toshio MaekawaShunsuke Ishii

Abstract

Telomeres maintain the integrity of chromosome ends and telomere length is an important marker of aging. The epidemiological studies suggested that many types of stress including psychosocial stress decrease telomere length. However, it remains unknown how various stresses induce telomere shortening. Here, we report that the stress-responsive transcription factor ATF7 mediates TNF-α-induced telomere shortening. ATF7 and telomerase, an enzyme that elongates telomeres, are localized on telomeres via interactions with the Ku complex. In response to TNF-α, which is induced by various stresses including psychological stress, ATF7 was phosphorylated by p38, leading to the release of ATF7 and telomerase from telomeres. Thus, a decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice. These findings give credence to the idea that various types of stress might shorten telomere.

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Citations

Nov 9, 2018·Nucleic Acids Research·Binbin LiuShunsuke Ishii
Jul 12, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Toshio MaekawaShunsuke Ishii
Jun 11, 2019·Drugs & Aging·Diana CrossleyElizabeth Sapey
Aug 21, 2020·Scientific Reports·Antti-Jussi ÄmmäläTiina Paunio
Jun 3, 2021·Cells·Maria Sol Jacome Burbano, Eric Gilson
Jul 20, 2021·IScience·Keisuke YoshidaShunsuke Ishii

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Methods Mentioned

BETA
PCR
immunoprecipitation
nuclear translocation
co-immunoprecipitation
Co-IP
pull-down
transfection
ChIP

Software Mentioned

Image Analyzer

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