ATGL and HSL are not coordinately regulated in response to fuel partitioning in fasted rats

The Journal of Nutritional Biochemistry
Fabrice Bertile, Thierry Raclot

Abstract

Prolonged fasting is characterized by lipid mobilization (Phase 2), followed by protein breakdown (Phase 3). Knowing that body lipids are not exhausted in Phase 3, we investigated whether changes in the metabolic status of prolonged fasted rats are associated with differences in the expression of epididymal adipose tissue proteins involved in lipid mobilization. The final body mass, body lipid content, locomotor activity and metabolite and hormone plasma levels differed between groups. Compared with fed rats, adiposity and epididymal fat mass decreased in Phase 2 (approximately two- to threefold) and Phase 3 (∼4.5-14-fold). Plasma nonesterified fatty acids (NEFA) concentrations were increased in Phase 2 (approximately twofold) and decreased in Phase 3 (approximately twofold). Daily locomotor activity was markedly increased in Phase 3 (∼11-fold). Compared with the fed state, expressions of adipose triglyceride lipase (ATGL; mRNA and protein), hormone-sensitive lipase (HSL; mRNA) and phosphorylated HSL at residue Ser660 (HSL Ser(660)) were increased during Phase 2 (∼1.5-2-fold). HSL (mRNA and protein) and HSL Ser(660) levels were lowered during Phase 3 (∼3-12-fold). Unlike HSL and HSL Ser(660), ATGL expression did not correlate w...Continue Reading

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Citations

Jun 13, 2014·Proteomics·Thierry WasselinFabrice Bertile
Apr 29, 2014·Journal of Hepatology·Cédric LanghiAngel Baldán
Jan 28, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Caroline LouisCathy Debier
May 2, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jian SunLi-Qiao Chen
Oct 27, 2016·Asian-Australasian Journal of Animal Sciences·Xiaoqiang YuZhisheng Wang
Aug 23, 2020·International Journal of Molecular Sciences·Marianne IbrahimFabrice Bertile
Aug 16, 2019·Molecular and Cellular Biochemistry·Sourashish NagTahir Hussain
Aug 10, 2019·Biological Chemistry·Marianne IbrahimFabrice Bertile
Sep 23, 2021·Scientific Reports·Sylvain GiroudStéphane Blanc

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