PMID: 9176833Jun 1, 1997Paper

Atherogenesis and the homocysteine-folate-cobalamin triad: do we need standardized analyses?

Journal of the American College of Nutrition
M A FlynnG Krause

Abstract

Bioscientists, physicians and nutritionists are newly interested in the homocysteine-folate-cobalamin triad, in part because homocysteine may be important both in atherogenesis and thrombogenesis. Homocysteine imbalance may be an early marker for cobalamin disorders because cobalamin is a cofactor in remethylation of homocysteine to methionine. In 139 men and 32 women of similar mean age of 65 years, we measured markers which have been cited as risk for atherosclerosis: serum homocysteine, folate, total cobalamin, holotranscobalamin I and II, (TCI and TCII), total serum cholesterol (SCHOL), high density lipoprotein cholesterol (HDLC), triglycerides (STG) as well as red blood cell (RBC) folate, food records and body composition by whole body counting of potassium-forty (40K). Statistical relationships among the data showed healthy women had lower mean serum homocysteine and their mean RBC folate and TCI and TCII were higher than men. Eighty-three subjects had TCII much lower than 60 pg/ml (subnormal), yet only 11 of these men and two women had total cobalamin < 200 pg/ml (abnormal). Fifty-two subjects with serum homocysteine greater than 17.5 nmol/ml had TCII less than 60 pg/ml, suggesting serum homocysteine may be a marker for ...Continue Reading

Citations

Aug 27, 2010·Archives of Gynecology and Obstetrics·Faruk AbikeLale Kutluay
Jun 11, 1999·Journal of the American Dietetic Association·S G Affenito, J Kerstetter
Jun 29, 2000·Journal of the American College of Nutrition·J C Essama-TjaniD Richard
Jul 11, 2001·Journal of the American College of Nutrition·P WhittakerJ I Rader
Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Johan Lökk
Jul 14, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·S-K MyungUNKNOWN Korean Meta-analysis (KORMA) Study Group

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