Abstract
Background and Aims: Atherosclerosis and osteoporosis share common risk factors, as well as inflammatory mechanisms. Our aim was to understand how atherosclerotic lesions are related with disturbances in bone. Methods: Gene expression of pro-inflammatory and bone metabolism related proteins (IL-1β, IL-6, IL-17A, TNF, RANKL, OPG, COL1, CTSK, OCL, TRAP, CBFA1, DKK1, SOST, ADIPOQ, and ADIPOR1) were analyzed in arteries and bones from 45 deceased donors and adipose tissue was used as control. Additionally, in 139 patients with advanced atherosclerosis submitted to carotid endarterectomy we compared calcium content (Alizarin red) and plaque inflammatory scores (CD3+, CD68+, and adiponectin) of patients with normal bone mineral density (BMD) with those with low BMD and explored the associations between gene expression in atherosclerotic plaques and BMD. Serum levels of pro-inflammatory and bone related proteins were measured both in donors and patients. Associations were investigated by the Pearson or Spearman correlation tests, and multivariate regression analyzes were performed when justified. Results: Gene expression of bone remodeling and pro-inflammatory proteins correlated positively in bone and aorta, independently of age and ...Continue Reading
References
Jan 1, 1997·The Journal of Pathology·J J Boyle
Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Terence M DohertyTripathi B Rajavashisth
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Gérard M LondonMarie-Christine de Vernejoul
Sep 9, 2004·American Journal of Epidemiology·Lone JørgensenBjarne K Jacobsen
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Eloy SchulzVicente Gilsanz
Jun 16, 2005·QJM : Monthly Journal of the Association of Physicians·D Hamerman
Nov 1, 2005·Scandinavian Journal of Urology and Nephrology·Neslihan SeyrekGulsah Seydaoglu
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
Jan 9, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M NavesJ B Cannata-Andía
Apr 9, 2008·Archives of Biochemistry and Biophysics·Brendan F Boyce, Lianping Xing
Oct 25, 2008·Gerontology·Peter PietschmannKatharina Kerschan-Schindl
Mar 24, 2009·Annual Review of Immunology·Elena Galkina, Klaus Ley
May 6, 2009·Biochemical Pharmacology·Alexander H Sprague, Raouf A Khalil
Oct 8, 2009·Circulation. Cardiovascular Imaging·James H F RuddZahi A Fayad
May 1, 2010·Endocrine Reviews·Stuart H Ralston, André G Uitterlinden
Aug 24, 2010·Maturitas·P PennisiC E Fiore
Jan 19, 2011·Arthritis Research & Therapy·Debby den UylWillem F Lems
May 28, 2011·Circulation Research·Sophie E P New, Elena Aikawa
Dec 2, 2011·Methods in Molecular Biology·Alun HughesVal Mann
Mar 14, 2012·Nature Reviews. Genetics·Christine Vogel, Edward M Marcotte
Sep 19, 2012·The Canadian Journal of Cardiology·Brian W WongBruce M McManus
Mar 27, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masashi HonmaHiroshi Suzuki
Apr 3, 2013·Clinical Reviews in Allergy & Immunology·Joana Caetano-LopesJoão E Fonseca
Apr 22, 2014·Patient Preference and Adherence·Tsuyoshi MiyazakiSakae Tanaka
May 20, 2014·Journal of Visualized Experiments : JoVE·Christian ErbelChristian A Gleissner
Dec 15, 2015·PloS One·Rita CascãoJoão E Fonseca
Jan 15, 2016·Journal of the American College of Cardiology·Francis R JoshiJames H F Rudd
Jul 1, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Monika FryszCelia L Gregson
Sep 2, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xiaowei HuangHairong Zheng
Dec 30, 2017·Stroke; a Journal of Cerebral Circulation·Xi-Ming YuanWei Li
Dec 28, 2019·PloS One·Jan GunsserAmelie Lupp