Atherosclerosis and pancreatic damage

Archives of Gerontology and Geriatrics
D RossoD Maugeri

Abstract

The appearance of diabetes in advanced age may be considered as a part of the involutive processes of aging, and as such, it might have a pathogenesis completely different from that of type 2 diabetes of medium age. As a matter of fact, it has been observed that the pancreas undergoes numerous structural and functional alterations with advancing age, both in exocrine and endocrine parts. The present studies have been performed to reveal the quantity and quality of the pancreatic lesions, which may be attributed to atherosclerosis. We have already studied elderly subjects, therefore, we were now looking for further supports in a population of middle age people, died in complications of malignant hypertension. We investigated the pancreas, kidney and heart of 36 subjects (20 males and 16 females) with mean age of 48.6+/-8.9 years. Of this group, eight subjects (22.2%) became diabetic after the appearance of malignant hypertension. Arteriolar atherosclerosis damage (hyalinosis, thickening and stenosis) of the pancreatic arterioles were found in 92.8% of the non-diabetic, and in 87.5% of the diabetic subjects. Lesions of the pancreatic islets were observed in 32% of the non-diabetics, and in 50% of the diabetic subjects. The pancre...Continue Reading

Citations

Oct 5, 2007·Archives of Gerontology and Geriatrics·Massimo MottaMariano Malaguarnera
Jul 26, 2005·Archives of Gerontology and Geriatrics·M MottaM Malaguarnera
Jul 4, 2009·Molecular Endocrinology·Jannick PétremandGérard Waeber

❮ Previous
Next ❯

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

Diabetes Care
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
G S Meneilly, D Tessier
Diabetic Medicine : a Journal of the British Diabetic Association
N UnwinK G M M Alberti
© 2021 Meta ULC. All rights reserved