Abstract
Thanks to the increasing knowledge of the pathogenesis of atherosclerosis, much effort has been made in the last years to develop new drugs aimed at controlling risk factors correlated with the disease as well as to investigate more deeply their mechanism of action. In particular, this brief review will describe some new aspects of the mechanism of action of drugs widely used in the control of risk factors like hyperlipemia, hypertension and blood viscosity. Among drugs active on plasma lipid profile, HMG-CoA reductase inhibitor are, at present, under study for their promising activity in the modulation of the interaction between the cells of the arterial wall and circulating blood elements. Indeed, these compounds have been found to control the proliferation of smooth muscle cells and other events related to the formation of atheroma. As far as antithrombotic drugs are concerned, the efficacy of low doses of aspirin has emerged by recent clinical trials. The successful use of low doses of aspirin has been possible following the comprehension of the mechanism by which this compound inhibits TXA-dependent platelet function, thus allowing a dose-dependent dissociation of the antithrombotic activity from other undesirable effects....Continue Reading
References
Sep 1, 1979·Lancet·J Dyerberg, H O Bang
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G J RothP W Majerus
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jun 1, 1991·Atherosclerosis·G SchmitzE M Kovacs
Oct 31, 1991·The New England Journal of Medicine·UNKNOWN Dutch TIA Trial Study GroupAnet van Latum
Dec 1, 1991·Circulation·T ForceP Weber
May 12, 1990·Lancet·P R LichtlenJ W Deckers
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H J KempenL M Havekes
Aug 1, 1990·Cardiovascular Drugs and Therapy·P R LichtlenJ W Deckers
Nov 8, 1990·The New England Journal of Medicine·J Loscalzo
Oct 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Sowers
Nov 1, 1989·Atherosclerosis·C L JacksonD E Bowyer
Feb 2, 1989·The New England Journal of Medicine·S EndresP C Weber
Oct 1, 1985·The Journal of Clinical Investigation·C von SchackyP C Weber
Jul 22, 1988·Science·P L Fox, P E DiCorleto
Nov 28, 1985·The New England Journal of Medicine·J A CairnsM G Myers
Jun 23, 1971·Nature: New Biology·J R Vane
Aug 18, 1983·The New England Journal of Medicine·H D LewisH DeMots
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T HenriksenD Steinberg
Feb 1, 1980·Thrombosis Research·C PatronoB A Peskar
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S YuiM Yamazaki
Mar 1, 1993·Circulation·L A HarkerW E Connor
Jan 1, 1992·Trends in Cardiovascular Medicine·C PatronoG Ciabattoni