Atherosclerosis, Hypertension, and Diabetes in Alzheimer's Disease, Vascular Dementia, and Mixed Dementia: Prevalence and Presentation

Journal of Alzheimer's Disease : JAD
Keivan JavanshiriElisabet Englund

Abstract

Alzheimer's disease (AD) is the most prevalent cause of dementia with vascular dementia (VaD) being second alongside with mixed AD and VaD, according to some. For some time, it has been proposed that cardiovascular disease (CaVD), hypertension, and diabetes mellitus (DM), which are known risk factors for VaD, also are associated with and contribute to the development of AD. The aim of this study was to investigate the prevalence of these proposed general risk factors, and to document presence of CaVD as evidenced from clinical records or from autopsy findings, further to correlate these with the diagnoses AD, VaD and mixed AD-VaD (MD), respectively. Autopsy reports at the Clinical Department of Pathology in Lund from 1992-2017 were analyzed. All cases with a complete autopsy report and a neuropathologically diagnosed dementia disorder (AD, VaD, or MD) were selected on the condition of a clinical diagnosis of dementia. Clinical data were retrieved through medical records and the Swedish National Diabetes Register (NDR). A total of 268 subjects were included. In AD, there was less CaVD as significantly less organ/tissue findings (p < 0.05), significantly less hypertension (p < 0.001), and likewise significantly less DM (p = 0.001...Continue Reading

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Citations

Aug 28, 2019·Journal of Alzheimer's Disease : JAD·Keivan JavanshiriElisabet Englund
Apr 25, 2020·Epidemiology and Psychiatric Sciences·Jesper Qvist ThomassenRuth Frikke-Schmidt
Apr 29, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Isabella Friis JørgensenSøren Brunak
May 30, 2020·Journal of Molecular Neuroscience : MN·Minzhen DengManting Huang
Dec 6, 2020·Current Opinion in Lipidology·Ida Juul RasmussenRuth Frikke-Schmidt
Apr 14, 2021·Clinical Chemistry·Jesper Qvist ThomassenRuth Frikke-Schmidt

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