Atherosclerosis in Asian Indians with systemic lupus erythematosus

Scandinavian Journal of Rheumatology
S P BhattS Shankar

Abstract

Atherosclerosis has emerged as an important late complication of systemic lupus erythematosus (SLE). Asian Indians, as an ethnic group, are known to be metabolically predisposed to development of early atherosclerosis. No data on this aspect of SLE are available from Asia. This study was undertaken to find the frequency of atherosclerosis in Indian lupus patients and the factors affecting such an occurrence. Carotid artery intimo-medial thickness (IMT) and plaque were used as markers of atherosclerosis. High-resolution B-mode ultrasonography was used to compare carotid IMT and plaque in 50 patients with SLE and 50 age- and sex-matched healthy controls. Patients with lupus (age 31.6+/-10.05, median 30.5 years; disease duration 52.3+/-36.7, median 46 months) exhibited a significantly greater IMT than controls (0.417+/-0.07 vs. 0.362+/-00.07 mm; p = 0.003). Carotid plaques were seen in seven (14%) cases. None of the control population had plaques (p = 0.006). On bivariate analysis, the IMT was significantly affected by age, systolic blood pressure (SBP), disease duration and menopausal status. On multivariate analysis, the only factor significantly affecting IMT was SBP. The Systemic Lupus International Collaborating Clinics/Ameri...Continue Reading

References

Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Aug 1, 1984·The American Journal of Medicine·J D HosenpudF E Kloster
Apr 18, 2000·Rheumatic Diseases Clinics of North America·I N BruceM B Urowitz
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 17, 2001·Circulation·E SvenungssonJ Frostegård
Dec 19, 2003·The New England Journal of Medicine·Mary J RomanJane E Salmon
Dec 19, 2003·The New England Journal of Medicine·Yu AsanumaC Michael Stein
Oct 30, 2004·Scandinavian Journal of Rheumatology·D O Haskard
Mar 30, 2005·Scandinavian Journal of Rheumatology·I MaraiY Shoenfeld
Mar 30, 2005·Scandinavian Journal of Rheumatology·S Wållberg-JonssonS Rantapää-Dahlqvist

❮ Previous
Next ❯

Citations

Dec 30, 2015·Seminars in Arthritis and Rheumatism·Konstantinos TseliosMurray B Urowitz
Sep 12, 2008·Best Practice & Research. Clinical Rheumatology·Mohammed Tikly, Sandra V Navarra
Jul 24, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroe SatoFumitake Gejyo
Nov 5, 2014·Nature Reviews. Rheumatology·Rohini Handa
Feb 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Pascal N TyrrellTimothy J Bradley
Nov 17, 2015·The Journal of Rheumatology·Konstantinos TseliosMurray B Urowitz
Oct 31, 2007·Arthritis and Rheumatism·Rohini Handa, Surya Prakash Bhatt
Mar 21, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Chun-Yan ZhangChun-De Bao
Jul 1, 2007·Expert Review of Clinical Immunology·Elena Bartoloni BocciRoberto Gerli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.