Atherosclerosis in Octodon degus (degu) as a model for human disease

Atherosclerosis
Reynold HomanBruce Taylor

Abstract

Animal models of atherosclerosis are essential to elucidate disease mechanisms and develop new therapies. Each model features advantages and disadvantages in exemplifying the pathophysiology of human atherosclerosis. Diet-induced development of atherosclerosis in Octodon degus (degu) was examined to demonstrate the potential of the degu as a model of human atherosclerosis. Degus were fed for 16 weeks with either normal chow or chow containing 0.25% cholesterol and 6% palm oil to induce atherosclerosis. The lipid compositions of plasma lipoproteins and aortas were determined. Locations of aortic lesions were mapped by imaging of fluorescently stained aortic lesions. Lesion morphology in the brachiocephalic artery was detected by histological staining. Total plasma cholesterol in chow-fed degus was distributed approximately 60% in HDL, 30% in LDL and less than 10% in VLDL. Cholesterol-fed degus exhibited 4- to 5-fold increases in total plasma cholesterol, principally in the VLDL and LDL fractions. Cholesteryl ester transfer protein activity of similar magnitude to that in human plasma was detected in chow-fed degu plasma. Cholesterol-fed degus developed cholesteryl ester-rich atherosclerotic lesions throughout the aorta. Histolog...Continue Reading

References

May 25, 1994·Nucleic Acids Research·C HadjiagapiouN O Davidson
Jan 1, 1993·Annual Review of Nutrition·D K SpadyJ M Dietschy
Jan 15, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Juan C OpazoFrancisco Bozinovic
Jan 31, 2004·ILAR Journal·Theresa M Lee
Mar 29, 2006·Nutrition & Metabolism·Maria Luz Fernandez, Jeff S Volek
Nov 23, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·James C Russell, Spencer D Proctor
May 26, 2007·Circulation Research·Willa HsuehIra J Goldberg
Jun 2, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Susanne ZadelaarTeake Kooistra
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

❮ Previous
Next ❯

Citations

May 29, 2013·CNS Neuroscience & Therapeutics·Ernesto TarragonMaria Trinidad Herrero
Dec 26, 2013·General and Comparative Endocrinology·Rene QuispeRodrigo A Vasquez
Aug 2, 2014·Progress in Neurobiology·Juvenal A RíosNibaldo C Inestrosa
May 1, 2021·Frontiers in Integrative Neuroscience·Lily Y-L ChangMonica L Acosta
Sep 17, 2021·Frontiers in Integrative Neuroscience·Daniela S RiveraNibaldo C Inestrosa
Apr 3, 2013·Cold Spring Harbor Protocols·Alvaro O ArdilesAdrian G Palacios

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.