Atherosclerosis: the importance of HDL cholesterol and prostacyclin: a role for niacin therapy

Medical Hypotheses
M H Luria

Abstract

Niacin reduces the incidence of non-fatal myocardial way infarction, confers a significant long-term survival benefit after recovery from myocardial infarction, and has had many years of study and usage by the medical community. Recent evidence suggests that via mechanisms which elevate HDL cholesterol and also release endogenous prostacyclin, niacin should be a potent agent in the long-term treatment of atherosclerosis.

References

Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Dec 8, 1988·The New England Journal of Medicine·G H Williams
Dec 1, 1988·Hypertension·R J GryglewskiJ R Vane
Mar 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D M Small
May 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R D AbbottW P Castelli
Dec 1, 1986·Journal of the American College of Cardiology·P L CannerW Friedewald
Nov 1, 1985·American Heart Journal·K M DetreR F Aldrich
Mar 28, 1985·The New England Journal of Medicine·A C ArntzeniusE A van der Velde
Mar 1, 1982·The Medical Clinics of North America·R M Krauss
Sep 1, 1980·Atherosclerosis·G Rosenhamer, L A Carlson
Oct 1, 1951·The American Journal of Medicine·D P BARRH A EDER

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Citations

Apr 1, 1993·Postgraduate Medical Journal·M H Luria, D Sapoznikov
Dec 4, 2015·The Journal of Pharmacology and Experimental Therapeutics·Lukasz MateuszukStefan Chłopicki
Jan 17, 1995·Annals of the New York Academy of Sciences·R J GryglewskiP Niezabitowski

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