Atherosclerosis-underlying inflammatory mechanisms and clinical implications

The International Journal of Biochemistry & Cell Biology
Sanjay PatelShisan Bao

Abstract

Inflammation plays an important role in the initiation and progression of atherosclerosis but many of its underlying mechanisms remain to be explored. Atherosclerotic plaques which are more prone to destabilisation and rupture, leading to clinical events, are characterised by increased infiltration of leukocytes and other inflammatory mediators, compared with stable fibrotic plaques. T cell mediated responses, through expression of cytokines and chemokines, play an important role in the inflammatory process; and more recently potentially anti-inflammatory markers have also been identified. Current management involves both mechanical restoration of blood flow and pharmacotherapy aimed in part at suppressing the underlying inflammatory mechanisms. The aims of this review are to outline the pro- and anti-inflammatory processes in atherosclerosis, as well as their clinical implications.

References

Nov 1, 1994·Annals of Internal Medicine·B KinosianG Garland
Mar 17, 1999·The Journal of Clinical Investigation·J GoslingI F Charo
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Apr 20, 2005·Journal of the American College of Cardiology·Rainer Schulz
May 14, 2005·Current Opinion in Lipidology·Stephen J NichollsPhilip J Barter
Feb 8, 2006·Nature Medicine·Hafid Ait-OufellaZiad Mallat
Apr 8, 2006·Physiological Reviews·Alain Tedgui, Ziad Mallat
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Mar 6, 2007·European Journal of Pharmacology·M Carmen DuránJesús Egido
Apr 6, 2007·The New England Journal of Medicine·Kiran Musunuru, Roger S Blumenthal

❮ Previous
Next ❯

Citations

Aug 1, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nagato KuriyamaMasanori Nakagawa
May 13, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Goran DamnjanovićStevan Ilić
Aug 15, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Uros ZoranovićMilica Cizmić
Jan 26, 2010·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Boris DjindjićMaja Bubanj
Aug 19, 2014·International Journal of Cardiology·Qiong XiaSanjay Patel
Oct 16, 2009·The International Journal of Biochemistry & Cell Biology·Peter UgocsaiGerd Schmitz
Oct 18, 2011·Immunopharmacology and Immunotoxicology·Jamal ShamsaraMohammad Ramezani
Oct 5, 2010·International Journal of Cardiology·Elias NajibShisan Bao
May 20, 2009·Experimental Eye Research·Masashi FujiharaJames T Handa
Apr 27, 2011·Hypertension·Charalambos AntoniadesChristodoulos Stefanadis
Jul 28, 2019·Biomolecules·Khojasteh MalekmohammadMahmoud Rafieian-Kopaei
Dec 28, 2019·Nutrition Journal·Celia BañulsAntonio Hernández-Mijares
Mar 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huan LiuYan Li
Sep 3, 2021·International Journal of Clinical Practice·Antonio CillaSergio Martínez-Hervás

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

The New England Journal of Medicine
G D Sloop
Circulation
Peter LibbyAttilio Maseri
Nature Reviews. Immunology
Göran K Hansson, Peter Libby
© 2021 Meta ULC. All rights reserved