Atherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Boun Kim TanANRS CO13 HEPAVIH study group

Abstract

An increased risk of cardiovascular disease (CVD) was reported in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), without identifying factors associated with atherosclerotic CVD (ASCVD) events. HIV-HCV coinfected patients were enrolled in the Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) CO13 HEPAVIH nationwide cohort. Primary outcome was total ASCVD events. Secondary outcomes were coronary and/or cerebral ASCVD events, and peripheral artery disease (PAD) ASCVD events. Incidences were estimated using the Aalen-Johansen method. Factors associated with ASCVD were identified using cause-specific Cox proportional hazards models. At baseline, median age of the study population (N = 1213) was 45.4 (interquartile range [IQR] 42.1-49.0) years and 70.3% were men. After a median follow-up of 5.1 (IQR 3.9-7.0) years, the incidence was 6.98 (95% confidence interval [CI], 5.19-9.38) per 1000 person-years for total ASCVD events, 4.01 (2.78-6.00) for coronary and/or cerebral events, and 3.17 (2.05-4.92) for PAD ASCVD events. Aging (hazard ratio [HR] 1.06; 95% CI, 1.01-1.12), prior CVD (HR 8.48; 95% CI, 3.14-22.91), high total cholesterol (HR 1.43; 95% CI, 1.11-1.83), high-d...Continue Reading

References

Dec 1, 2006·The New England Journal of Medicine·UNKNOWN Strategies for Management of Antiretroviral Therapy (SMART) Study GroupC Rappoport
May 11, 2010·AIDS·UNKNOWN Data Collection on Adverse Events of Anti-HIV drugs (D:A:D) Study GroupSigne W Worm
Jun 30, 2011·Circulation. Cardiovascular Quality and Outcomes·Matthew S FreibergUNKNOWN Veterans Aging Cohort Study
Mar 16, 2012·Atherosclerosis·Philippe SosnerChristine Silvain
Jul 24, 2012·JAMA : the Journal of the American Medical Association·Sharath SubramanianSteven K Grinspoon
Feb 2, 2013·Journal of the American College of Cardiology·Franck BoccaraAriel Cohen
Mar 6, 2013·JAMA Internal Medicine·Matthew S FreibergAmy C Justice
Jan 17, 2014·The New England Journal of Medicine·Mark S SulkowskiUNKNOWN AI444040 Study Group
Apr 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adeel A ButtUNKNOWN ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) Study Team
Apr 12, 2015·Neurology·Jason J SicoUNKNOWN Veterans Aging Cohort Study
May 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meredith E ClementSusanna Naggie
Jun 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philippe SogniLinda Wittkop
Sep 10, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Gregory M LucasJames H Stein
Jan 22, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan BerenguerUNKNOWN GESIDA HIV/HCV Cohort Study Group
Apr 27, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtMatthew S Freiberg
May 19, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel R DrozdHeidi M Crane
Mar 15, 2018·Circulation·Joshua A BeckmanMatthew S Freiberg
Apr 15, 2018·American Heart Journal·Patrice CacoubUNKNOWN ANRS CO12 CirVir group
Jul 10, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Andreas D KnudsenSusanne D Nielsen

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