Atherothrombosis: a widespread disease with unpredictable and life-threatening consequences

European Heart Journal
Juan F Viles-GonzalezJuan J Badimon

Abstract

Atherothrombosis, characterised by atherosclerotic lesion disruption with superimposed thrombus formation, is the major cause of acute coronary syndromes (ACS) and cardiovascular death. It is the leading cause of mortality in the industrialised world. Atherosclerosis is a diffuse process that starts early in childhood and progresses asymptomatically through adult life. Later in life, it is clinically manifested as coronary artery disease, stroke, transient ischaemic attack, and peripheral arterial disease. From the clinical point of view, we should envision this disease as a single pathologic entity that affects different vascular territories. Available antithrombotic therapy is very safe and efficient but the morbidity and mortality due to atherothrombosis is still unacceptably high. Recent evidence suggests that inhibition of tissue factor or elements in the tissue factor pathway (i.e., factors VIIa and Xa, or thrombin) has the potential to further improve outcomes in atherothrombosis. Here, we will review the most important concepts and advances in the pathogenesis, prevention, and antithrombotic treatment of this widespread disease.

Citations

Jul 3, 2013·Cardiovascular Drugs and Therapy·Qian ZhangXiao Dan Fu
Feb 16, 2010·Journal of Thrombosis and Thrombolysis·Milan PopovićYves Laumonnier
Apr 10, 2009·Cell Stress & Chaperones·A Graham PockleyGabriele Multhoff
May 31, 2012·European Heart Journal Cardiovascular Imaging·Stijn C H van den OordArend F L Schinkel
Nov 21, 2007·Topics in Magnetic Resonance Imaging : TMRI·Tomas HansenLars Johansson
Nov 29, 2007·Cerebrovascular Diseases·Carmen Suárez, UNKNOWN Spanish investigators of REACH
Apr 16, 2011·BMC Cardiovascular Disorders·Nikos ManiadakisVasileios Fragoulakis
Jun 10, 2010·Vascular Health and Risk Management·Lars MaegdefesselPhilip S Tsao
Nov 2, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Steven R Steinhubl, David J Moliterno
Dec 17, 2008·Journal of Atherosclerosis and Thrombosis·Lale Tokgözoğlu, Ergün Bariş Kaya
Aug 27, 2013·Current Psychiatry Reports·Angelos Halaris
May 25, 2010·Current Cardiology Reports·Guliz ErdemMarcus D Flather
Oct 27, 2004·Expert Opinion on Investigational Drugs·Juan F Viles-GonzalezJuan J Badimon
Sep 20, 2015·Journal of Thrombosis and Haemostasis : JTH·H WangD T Eitzman
Mar 21, 2013·Heart, Lung & Circulation·Zanfina AdemiChristopher M Reid
Feb 7, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Akio IioMasafumi Ito
Nov 8, 2011·Revista Española De Cardiología·Guliz Erdem, Marcus Flather
Apr 6, 2011·European Journal of Pharmacology·Somsuvra B GhatakShital J Panchal
Apr 28, 2009·Medicina clínica·Carmen SuárezUNKNOWN en representación de los investigadores del registro REACH España
Feb 17, 2009·International Journal of Cardiology·G F GensiniUNKNOWN Achieve Cholesterol Targets Fast withAtorvastatin Stratified Titration Investigators
Oct 18, 2015·Regulatory Toxicology and Pharmacology : RTP·Robyn L PrueittJulie E Goodman
Nov 11, 2008·International Immunopharmacology·Huang-Joe WangHuey-Chun Huang
Mar 7, 2007·Revista española de cardiología·Carlos Lahoz, José M Mostaza
Jul 28, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Charles J GlueckPing Wang
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·J F Viles-Gonzalez, V Fuster
Aug 20, 2009·Cardiovascular Therapeutics·Zanfina AdemiUNKNOWN REACH registry investigators

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