Atherothrombosis and the management of the vulnerable vascular patient

American Journal of Therapeutics
Rohit R Arora, Fasi Rai

Abstract

Atherothrombosis is a generalized and diffuse progressive process manifesting in multiple vascular beds leading to acute coronary syndrome (ACS), ischemic stroke, and peripheral arterial disease. The American Heart Association estimates the prevalence of ischemic stroke, coronary heart disease, and peripheral artery disease to be 4.8, 13.2, and 8 million, respectively. According to the World Health Organization, in 2004, atherothrombosis was the leading cause of death worldwide. Twenty-two percent of all deaths are attributed to atherothrombosis, which is greater than the percentage of deaths from AIDS and cancer combined. Data from the Framingham Heart Study has shown atherothrombosis significantly reduces life expectancy. According to current data, there is an established relationship among coronary artery disease, peripheral vascular disease, and cardiovascular disease. The REACH registry demonstrated that the 1-year cardiovascular event rates increase with the number of symptomatic disease locations. Unstable angina/non-ST-segment elevation MI is a major public health problem and represents the most common reason for hospital admission for coronary heart disease. Classification of "vulnerable patients" will help identify th...Continue Reading

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