ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis

Pharmacogenomics
N MuralidharanV S Negi

Abstract

To find the association of ATIC 347C>G gene polymorphism with methotrexate (MTX) treatment response and MTX-induced adverse events in south Indian Tamil patients with rheumatoid arthritis. A total of 319 rheumatoid arthritis and 310 healthy controls were recruited for the study and ATIC 347C>G gene polymorphism was analyzed by PCR-RFLP method. The genotype and allele frequencies of ATIC 347 C>G SNP did not differ between good and nonresponders and hence this SNP was not found to be associated with MTX treatment response. However, the ATIC 347 GG genotype (p = 0.02; odds ratio [OR]: 4.46; 95% CI: 1.28-15.52) and mutant G allele was associated with MTX-induced gastrointestinal adverse events (p = 0.01; OR: 2.60; 95% CI: 1.27-5.35). ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events.

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
May 8, 1998·Seminars in Arthritis and Rheumatism·A E van EdeL B van de Putte
Jun 8, 2002·Pharmacogenomics·Cornelia M UlrichRachel Sparks
May 26, 2005·Pharmacological Reviews·Bruce N Cronstein
Apr 6, 2007·The Journal of Investigative Dermatology·Emanuela CampalaniCatherine H Smith
May 12, 2009·Trends in Immunology·György HaskóPál Pacher
Dec 1, 2009·Autoimmunity Reviews·Gabriel J TobónAlain Saraux
Feb 25, 2011·Current Opinion in Rheumatology·Cornelia F Allaart, Tom W J Huizinga
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Feb 24, 2012·Clinical Pharmacology and Therapeutics·Inés ColmegnaHenri A Menard
Mar 3, 2012·Pharmacogenomics·Prabha Ranganathan
Jun 12, 2012·Arthritis Research & Therapy·Lisa K StampPaul A Hessian

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Citations

Oct 19, 2019·The Pharmacogenomics Journal·Frank EektimmermanHenk-Jan Guchelaar
Dec 2, 2017·Clinical Genetics·S TavakolpourM Ghasemiadl
Aug 28, 2020·Journal of Ophthalmology·Ge Wang, Xiaoyan Peng
Sep 22, 2018·The Pharmacogenomics Journal·Andrea Giletti, Patricia Esperon
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S JayashreeDipita Bhakta-Guha

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Methods Mentioned

BETA
genotyping
PCR
ELISA

Software Mentioned

CaTS
SPSSv16
GraphPad Instat

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