PMID: 8587149Oct 1, 1995Paper

Atipamezole increases medetomidine clearance in the dog: an agonist-antagonist interaction

Journal of Veterinary Pharmacology and Therapeutics
S SalonenM Anttila

Abstract

Medetomidine, an alpha 2-adrenoceptor agonist, is a potent sedative and analgesic agent in the dog. When necessary, its action can be effectively antagonized by atipamezole. The present work was designed to study the effects of these drugs on each others' pharmacokinetics when a single intramuscular dose of medetomidine (50 micrograms kg-1) was followed by a dose of atipamezole (250 micrograms kg-1). Three different treatments were used: medetomidine alone, atipamezole alone, and atipamezole after medetomidine. Drug concentrations in plasma were measured by GC-MS. Statistical analysis of the results (ANOVA) revealed significant differences between treatments in the kinetic parameters of medetomidine. Atipamezole decreased the AUC of medetomidine from 41.3 to 28.6 ng h ml-1 (P = 0.005), t1/2 from 1.44 to 0.87 h (P = 0.015), and increased Cl from 21 to 31 ml min-1 kg-1 (P = 0.017). Differences in Vz did not reach statistical significance. The only statistically significant effects of medetomidine on the pharmacokinetics of atipamezole in this study were the slight decrease of Cl and Cmax as well as the increase of AUC. It is suggested that the large dose of medetomidine used caused haemodynamic changes, resulting in decreased hep...Continue Reading

References

Jun 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·A T Vähä-Vahe
May 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J S Salonen, M Eloranta
Jun 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·O VainioL Palmu
Dec 1, 1986·Journal of Autonomic Pharmacology·J M SavolaN T Kärki
Dec 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·D StenbergM V Miettinen

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Citations

May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·K A GrimmG J Benson
Jan 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·B RanheimT E Horsberg
Apr 4, 2000·Journal of Veterinary Pharmacology and Therapeutics·E KuuselaO Vainio
Feb 13, 2001·Journal of Veterinary Pharmacology and Therapeutics·B RanheimT E Horsberg
Apr 26, 2014·American Journal of Veterinary Research·Bruno H Pypendop, Jan E Ilkiw
Apr 17, 2015·Veterinary Anaesthesia and Analgesia·Eduardo R MonteiroBetânia S Monteiro
Jan 15, 2016·Journal of Veterinary Pharmacology and Therapeutics·R C BennettO M Vainio
Apr 9, 2008·Journal of Medical Primatology·Betty R TheriaultMarek A Niekrasz
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·S B R KästnerM K Huhtinen
Feb 2, 2012·Journal of Veterinary Pharmacology and Therapeutics·B H PypendopJ E Ilkiw
Sep 5, 2012·Journal of Veterinary Pharmacology and Therapeutics·K I CrookM G Papich
Jan 9, 2008·Veterinary Anaesthesia and Analgesia·Guan-Yu LinLudo J Hellebrekers
Nov 25, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Juhana HonkavaaraMika Scheinin
Jan 17, 2021·Veterinary Anaesthesia and Analgesia·Avishag TuvalYael Shilo-Benjamini
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Paloma Nicolás-BarcelóFrancisco Javier Duque

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