PMID: 8946274Nov 1, 1996Paper

ATL and HTLV-I: in vivo cell growth of ATL cells

Journal of Clinical Immunology
T Uchiyama

Abstract

The mechanism of leukemogenesis or neoplastic cell growth in adult T cell leukemia (ATL) still remains unclear, although Tax of human T cell leukemia/lymphoma virus type I (HTLV-I), the etiologic virus, has been reported to affect the expression of various cellular genes which encode molecules involved in cell growth or cell death. We have studied the cell growth of HTLV-I-infected human T cells in severe combined immunodeficiency (SCID) mice and found that fresh leukemic cells or cell lines derived from leukemic cell clones but not HTLV-I-infected cell lines of nonleukemic cell origin showed tumorigenicity, and neither HTLV-I nor IL-2 expression was needed for cell growth in vivo, indicating that accumulating changes in addition to the initial events induced by HTLV-I infection were required for the development of ATL. The interaction between ATL cells and vascular endothelial cells appears to be one of the important factors which determine the pattern of organ infiltration by leukemic cells. E-selectin and its ligand are one of the major cell adhesion pathways between ATL cells and human umbilical vein endothelial cells (HUVEC). Another pathway that had not been identified was studied using newly developed monoclonal antibodi...Continue Reading

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Citations

Apr 25, 2000·Biochemical and Biophysical Research Communications·Y SatakeK Okumura
Jun 8, 1999·Journal of the National Cancer Institute·K V Kibler, K T Jeang
Jan 1, 1998·Hematology·F Ravandi-KashaniF J Giles
Jan 1, 2013·Virology : Research and Treatment·Amanda R PanfilPatrick L Green
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R PankowS Bulfone-Paus
Apr 13, 2018·Frontiers in Microbiology·Sara MoodadHiba El Hajj

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