Atlantic cod (Gadus morhua) larvae can biosynthesis phospholipid de novo from 2-oleoyl-glycerol and glycerol precursors

Fish Physiology and Biochemistry
Keshuai LiY Olsen

Abstract

The dietary requirement of phospholipid (PL) of fish larvae has been suggested to originate in an inefficient ability for de novo biosynthesis of PL based on dietary triacylglycerol (TAG). The main objective of the present study was to investigate whether cod larvae could synthesis PL from sn-2-monoacylglycerol (2-MAG) and glycerol precursors. A tube feeding method was used to deliver equal molar aliquots of 2-oleoyl-[1,2,3-(3)H]glycerol and [U-(14)C] glycerol together with bovine serum albumin (BSA) bound 16:0 (palmitic acid) and 22:6n-3 (docosahexaenoic acid, DHA), with or without choline chloride to the foregut of anesthetized cod larvae and thereafter monitoring the metabolism of these components in the larvae through 4 h following injection. Our results showed that both 2-MAG and glycerol precursors contributed to the de novo synthesis of phosphatidylcholine (PC) and the 2-MAG pathway predominated over the G-3-P (glycerol-3-phosphate) pathway in the synthesis of TAG and PC. The molecular ratio of PC/TAG obtained from the 2-MAG and the G-3-P pathways was 0.44-0.74 and 1.02-2.06 within the first hour of tube feeding, suggesting they might have comparable biosynthesis ability of PC and TAG under the conditions of the present ...Continue Reading

References

Aug 1, 1977·The Journal of Clinical Investigation·C M Mansbach
Apr 23, 1992·Biochimica Et Biophysica Acta·R Lehner, A Kuksis
Apr 1, 1986·Journal of Animal Science·L L SouthernM C Fox
Jan 1, 1996·Progress in Lipid Research·R Lehner, A Kuksis
Jan 1, 1997·Sub-cellular Biochemistry·F KuipersA K Groen
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jean E Vance, Dennis E Vance
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Toyonori KatoHiroaki Yuasa
Mar 8, 2005·Biochimica Et Biophysica Acta·Claudia Kent
Apr 12, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Anthony OxleyRolf E Olsen
Nov 28, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Anthony OxleyRolf Erik Olsen
May 11, 2007·The American Journal of Clinical Nutrition·Leslie M FischerSteven H Zeisel
Jan 22, 2008·Journal of Lipid Research·Zhaoyu Li, Dennis E Vance
Feb 26, 2008·Progress in Lipid Research·Hiroyuki SugimotoDennis E Vance
Dec 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kotaro HamaSteven A Farber
Jan 27, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Inge GeurdenKristina S Sundell
Jan 1, 1947·Annual Review of Biochemistry·T H JUKES
Aug 13, 2011·Nature·Bastiaan StarKjetill S Jakobsen
Feb 26, 2015·Journal of Lipid Research·Shahzad Siddiqi, Charles M Mansbach
Aug 28, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Keshuai LiYngvar Olsen

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