Atlas-based semiautomatic target volume definition (CTV) for head-and-neck tumors

International Journal of Radiation Oncology, Biology, Physics
Gerd StrassmannRita Engenhart-Cabillic

Abstract

To develop a new semiautomatic method to improve target delineation in head-and-neck cancer. We implemented an atlas-based software program using fourteen anatomic landmarks as well as the most superior and inferior computerd tomography slices for automatic target delineation, using an advanced laryngeal carcinoma as an example. Registration was made by an affine transformation. Evaluation was performed with manually drawn contours for comparison. Three physicians sampled and further applied a target volume atlas to ten other computer tomography data sets. In addition, a rapid three-dimensional (3D) correction program was developed. The mean time to the first semiautomatic target delineation proposal was 2.7 minutes. Manual contouring required 20.2 minutes per target, whereas semiautomatic target volume definition with the rapid 3D correction was completed in only 9.7 minutes. The net calculation time for image registration of the target volume atlas was negligible (approximately 0.6 seconds). Our method depicted a sufficient adaptation of the target volume atlas on the new data sets, with a mean similarity index of 77.2%. The similarity index increased up to 85% after 3D correction performed by the physicians. We have develope...Continue Reading

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Citations

Nov 21, 2012·Nature Reviews. Clinical Oncology·Philippe LambinAndre Dekker
Jul 23, 2011·Medical Physics·Vorakarn ChanyavanichJoseph Y Lo
Jan 18, 2016·Advanced Drug Delivery Reviews·Philippe LambinSean Walsh
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Sep 9, 2015·Physics in Medicine and Biology·Yang ShengQ Jackie Wu

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