Atlas-guided prostate intensity modulated radiation therapy (IMRT) planning

Physics in Medicine and Biology
Yang ShengQ Jackie Wu

Abstract

An atlas-based IMRT planning technique for prostate cancer was developed and evaluated. A multi-dose atlas was built based on the anatomy patterns of the patients, more specifically, the percent distance to the prostate and the concaveness angle formed by the seminal vesicles relative to the anterior-posterior axis. A 70-case dataset was classified using a k-medoids clustering analysis to recognize anatomy pattern variations in the dataset. The best classification, defined by the number of classes or medoids, was determined by the largest value of the average silhouette width. Reference plans from each class formed a multi-dose atlas. The atlas-guided planning (AGP) technique started with matching the new case anatomy pattern to one of the reference cases in the atlas; then a deformable registration between the atlas and new case anatomies transferred the dose from the atlas to the new case to guide inverse planning with full automation. 20 additional clinical cases were re-planned to evaluate the AGP technique. Dosimetric properties between AGP and clinical plans were evaluated. The classification analysis determined that the 5-case atlas would best represent anatomy patterns for the patient cohort. AGP took approximately 1 mi...Continue Reading

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Citations

Aug 4, 2018·The British Journal of Radiology·Mohammad HusseinAndrew Nisbet
Sep 13, 2019·Technology in Cancer Research & Treatment·Yang ShengYaorong Ge
Jun 14, 2020·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Suhong YuKimberley Mak
Jun 24, 2021·Clinical and Translational Radiation Oncology·David J SherMu-Han Lin
Jul 8, 2021·Journal of Applied Clinical Medical Physics·Shadab MominXiaofeng Yang
Jul 9, 2021·Physics in Medicine and Biology·Jiayuan PengWeigang Hu

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