ATM gene single nucleotide polymorphisms predict regimen-related gastrointestinal toxicity in patients allografted after reduced conditioning

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Adam KubaTomas Papajik

Abstract

Polymorphisms of genes involved in innate and adaptive immunity have become an object of major interest in regard to hematopoietic stem cell transplantation (HSCT) complications. Regimen-related gastrointestinal toxicity (RR-GIT) is the dominant complication during the pre-engraftment period and has been linked to increased risk of graft-versus-host disease (GVHD) development. According to our hypothesis, functional variants of genes participating in DNA damage response (DDR) may have an impact on the extent of tissue damage caused by the conditioning regimen. In our single-center study, we analyzed 62 patients who underwent HSCT from HLA-identical donors after reduced conditioning. The patients were genotyped for 5 single nucleotide polymorphisms (SNPs, rs4585 T/G, rs189037 A/G, rs227092 T/G, rs228590 C/T, and rs664677 T/C) of the ATM gene-the essential member of the DDR pathways, using allele-specific matrix-assisted laser desorption/ionization, time-of-flight (MALDI-TOF) mass spectrometry assay. Because of almost absolute linkage disequilibrium observed among all 5 SNPs, association of 2 major ATM haplotypes (ATM1/ATM2) with RR-GIT and acute GVHD (aGVHD) was analyzed. Importantly, the univariate and multivariate analysis sho...Continue Reading

References

Jan 1, 1981·Cancer·A B MillerA Winkler
Apr 29, 1998·American Journal of Human Genetics·S GiladA Bar-Shira
May 20, 1999·American Journal of Human Genetics·S N TeraokaP Concannon
Feb 1, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jenna GoldbergGeorgia B Vogelsang
Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoMary Horowitz
Dec 1, 2009·Bone Marrow Transplantation·S PaczesnyP Reddy
Dec 17, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yen-Li LoChao A Hsiung
Feb 23, 2010·International Journal of Radiation Oncology, Biology, Physics·Li ZhangLuhua Wang
May 7, 2010·Trends in Molecular Medicine·Adam FreundJudith Campisi
Jun 16, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daihong LiuXiaojun Huang
Jun 7, 2011·Bone Marrow Transplantation·A Gratwohl
Jun 2, 2012·Blood·Anne M Dickinson
Nov 17, 2012·International Journal of Radiation Oncology, Biology, Physics·Huihua XiongQingyi Wei
Aug 21, 2013·International Journal of Hematology·Sophie PaczesnyChristy Mumaw
Sep 5, 2013·Cold Spring Harbor Perspectives in Biology·Alexandre Maréchal, Lee Zou

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Citations

Jul 15, 2016·Molecular Cancer Therapeutics·Michael ChoiRazelle Kurzrock

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