ATM haplotypes and breast cancer risk in Jewish high-risk women.

British Journal of Cancer
M KorenEitan Friedman

Abstract

While genetic factors clearly play a role in conferring breast cancer risk, the contribution of ATM gene mutations to breast cancer is still unsettled. To shed light on this issue, ATM haplotypes were constructed using eight SNPs spanning the ATM gene region (142 kb) in ethnically diverse non-Ashkenazi Jewish controls (n=118) and high-risk (n=142) women. Of the 28 haplotypes noted, four were encountered in frequencies of 5% or more and accounted for 85% of all haplotypes. Subsequently, ATM haplotyping of high-risk, non-Ashkenazi Jews was performed on 66 women with breast cancer and 76 asymptomatic. One SNP (rs228589) was significantly more prevalent among breast cancer cases compared with controls (P=4 x 10(-9)), and one discriminative ATM haplotype was significantly more prevalent among breast cancer cases (33.3%) compared with controls (3.8%), (P< or =10(-10)). There was no significant difference in the SNP and haplotype distribution between asymptomatic high-risk and symptomatic women as a function of disease status. We conclude that a specific ATM SNP and a specific haplotype are associated with increased breast cancer risk in high-risk non-Ashkenazi Jews.

References

Dec 26, 1991·The New England Journal of Medicine·M SwiftC L Chase
May 21, 1987·The New England Journal of Medicine·M SwiftC L Chase
Mar 1, 1997·Nature Genetics·M G FitzGeraldD A Haber
Dec 31, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·D P LittleH Köster
Mar 31, 1999·British Journal of Cancer·H M InskipC F Arlett
Nov 11, 1999·Oncogene·G Rotman, Y Shiloh
Mar 21, 2000·American Journal of Human Genetics·A BroeksL J van 't Veer
Apr 18, 2000·Mutation Research·S Angèle, J Hall
May 18, 2000·Journal of the National Cancer Institute·K K Khanna
Sep 12, 2000·Human Mutation·K LaakeA L Børresen-Dale
Feb 24, 2001·Journal of the National Cancer Institute·J H OlsenM Tucker
Mar 21, 2001·Human Molecular Genetics·K L Nathanson, B L Weber
Feb 7, 2002·Journal of the National Cancer Institute·Georgia Chenevix-TrenchKum Kum Khanna
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kui ZhangFengzhu Sun
Jun 26, 2004·Breast Cancer Research : BCR·Rulla M TamimiDavid J Hunter
Sep 3, 2004·Nature Reviews. Cancer·Steven A Narod, William D Foulkes
Nov 24, 2004·Journal of Mammary Gland Biology and Neoplasia·Deborah Thompson, Douglas Easton
Dec 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gad Kimmel, Ron Shamir
Jan 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judy E Garber, Kenneth Offit
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoung-Mu LeeDaehee Kang
Jun 2, 2005·Journal of the National Cancer Institute·Deborah ThompsonDouglas F Easton

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Citations

Sep 18, 2007·Nature Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Donghui LiJames L Abbruzzese
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary E SehlPatricia A Ganz
Aug 30, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yadong WangYuxin Zheng
Sep 13, 2011·Genes, Chromosomes & Cancer·Idoia Martín-GuerreroAfrica García-Orad
Mar 3, 2007·Breast Cancer Research and Treatment·Ariel E HirschBarry S Rosenstein
Apr 14, 2007·Breast Cancer Research and Treatment·Chuanzhong YeWei Zheng
Jun 22, 2007·International Journal of Cancer. Journal International Du Cancer·Hushan YangXifeng Wu
Mar 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Li XuLaura S Ward
Feb 18, 2011·Breast Cancer Research and Treatment·Bo JinZhishan Ding
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Manjula GorreVishnupriya Satti
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Leon RaskinStephen B Gruber

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping
chip

Software Mentioned

SpectroDESIGNER
GERBIL

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