ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence

Molecular Cell
Marek Kozlowski, Andreas G Ladurner

Abstract

Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence.

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Citations

Oct 17, 2017·Expert Review of Clinical Immunology·Majid Zaki-DizajiAsghar Aghamohammadi
Aug 3, 2016·Science Advances·Sangita Pal, Jessica K Tyler
Apr 16, 2016·F1000Research·Surinder Kumar, David B Lombard
Mar 2, 2019·Critical Reviews in Biochemistry and Molecular Biology·Alice E Kane, David A Sinclair
Dec 21, 2017·Inflammation and Regeneration·Takao Ito, Tatsushi Igaki
Nov 6, 2018·Aging·Na Yang, Payel Sen
Dec 22, 2016·Frontiers in Endocrinology·Ufuk Degirmenci, Sun Lei
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Xueke ZhouXin Li

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