Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip

Nanoscale
Yan LiXu Yang

Abstract

Inhaled atmospheric nanoparticles (ANPs) can migrate into human blood vessels. However, the exact pathogenesis has not yet been well elucidated. In this study, a perfusable 3D human microvessel network was constructed in a microfluidic device. This functional 3D micro-tissue partly mimicked the physiological response of human vessels. Intravascular nanoparticles tend to adsorb proteins to form a protein corona. Based on this pathological response, vessel permeability and vasoconstriction resulting from ANP stimulation might be related to vascular inflammation. It mediated abnormal expression of nuclear factor-κB (NF-κB) and an influx of intracellular Ca2+ ([Ca2+]i). This biological behavior disturbed the normal expression of intercellular cell adhesion molecule 1 (ICAM-1) and vascular endothelial growth factor (VEGF). The imbalance of nitric oxide (NO) and endothelin-1 (ET-1) further resulted in endothelial cell contraction. All these bio-events induced the loss of tight junctions (ZO-1) which enhanced vessel permeability. Meanwhile, ANP induced-vascular toxicity was also found in mice. Our observations provide a plausible explanation for how the ANPs affect human vascular function. The vessel-on-chip provides a bridge between ...Continue Reading

References

Nov 13, 1999·Circulation Research·C Fernandez-PatronS T Davidge
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A NemmarB Nemery
Jan 18, 2003·Vascular Pharmacology·Hartwig Wolburg, Andrea Lippoldt
May 16, 2003·Vascular Pharmacology·Chinnaswamy TiruppathiAsrar B Malik
Oct 22, 2003·Circulation·Paul E SzmitkoSubodh Verma
May 1, 2004·Critical Care Medicine·Charles T Esmon
Aug 5, 2005·Environmental Health Perspectives·Ralph J DelfinoShaista Malik
Jan 6, 2006·Environmental Health Perspectives·Mark W FramptonMark J Utell
Mar 18, 2006·Thrombosis and Haemostasis·Gianfranco Bazzoni
Nov 7, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Chinnaswamy TiruppathiAsrar B Malik
Dec 20, 2007·Journal of Cardiovascular Pharmacology·Marc Iglarz, Martine Clozel
Mar 25, 2008·International Journal of Pharmaceutics·Wei YangRobert O Williams
May 30, 2008·American Journal of Physiology. Cell Physiology·Philippe G FrankMichael P Lisanti
Jun 12, 2008·Tissue Engineering. Part B, Reviews·Tamer A E AhmedMax Hincke
Jul 17, 2008·Environmental Health Perspectives·Alon PeretzJoel D Kaufman
Jan 17, 2009·Philosophy, Ethics, and Humanities in Medicine : PEHM·Niall ShanksJean Greek
Apr 24, 2009·Advanced Drug Delivery Reviews·Kristin L AillonM Laird Forrest
May 28, 2009·Biotechnology and Bioengineering·Mark W Tibbitt, Kristi S Anseth
Jul 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yeela Talmor-BarkanSydney Benchetrit
Sep 11, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toby M Maher, Athol U Wells
Apr 20, 2010·American Journal of Ophthalmology·Joseph CaprioliUNKNOWN Blood Flow in Glaucoma Discussion
Dec 21, 2010·Nature Nanotechnology·Zhou J DengRodney F Minchin
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ioannis K ZervantonakisRoger D Kamm
May 8, 2013·European Journal of Internal Medicine·Nicola MartinelliDomenico Girelli
Mar 25, 2014·Colloids and Surfaces. B, Biointerfaces·Joy WolframYuliang Zhao
Jun 10, 2014·Journal of Cellular Physiology·Maddaly RaviF D Paul Solomon
Jul 30, 2014·Toxicological Research·Byeong-Jae LeeKyuhong Lee
Aug 6, 2014·Nature Biotechnology·Sangeeta N Bhatia, Donald E Ingber
Dec 3, 2014·Environment International·Ki-Hyun KimShamin Kabir
Dec 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jessie S JeonRoger D Kamm
Jan 7, 2015·Chemical Research in Toxicology·Ruijin LiChuan Dong
Feb 24, 2016·Frontiers in Bioengineering and Biotechnology·Moriah E KattPeter C Searson
Jun 16, 2016·Nanoscale·Zhuang Liu, Samuel Achilefu

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Citations

Jan 22, 2020·Annual Review of Analytical Chemistry·Olivier T GuenatFrançois Berthiaume
Mar 6, 2021·Bioactive Materials·Rick Xing Ze Lu, Milica Radisic

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Methods Mentioned

BETA
chip
confocal microscopy
fluorescence
chips
biopsy

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