Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells

Oncology Letters
Qian ZhangZhongwei Lv

Abstract

Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was to explore the response of the HCC cell lines HepG2 and HuH-7 to PM2.5 exposure. The results revealed that PM2.5 treatment promoted the migration and invasion of HCC cells, in addition to increasing protein levels of matrix metalloproteinase (MMP)-13. Additionally, PM2.5 induced intracellular reactive oxygen species formation in HCC cells. Further investigation revealed that phosphorylation of RAC-alpha serine/threonine-protein kinase (AKT) increased in response to PM2.5 exposure in HCC cells, and the AKT antagonist LY294002 reduced PM2.5-induced migration, invasion and MMP-13 expression. In addition, the data from the present study demonstrated that high concentrations of PM2.5 decreased the proliferation of normal HL7702 hepatocyte cells and promoted apoptosis. These results indicate that the activation of AKT by PM2.5 results in MMP-13 overexpression, and stimulates HCC cell migration and invasion. In conclusion,...Continue Reading

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Citations

Jul 25, 2019·International Journal of Environmental Research and Public Health·Chern-Horng LeeTzung-Hai Yen
Dec 28, 2019·International Journal of Molecular Sciences·Miguel Santibáñez-AndradeClaudia M García-Cuellar
Apr 27, 2018·Cancer Causes & Control : CCC·Trang VoPhamJaime E Hart
Jan 12, 2021·The Science of the Total Environment·Rongrong WangChunzhen Shi
Jul 16, 2021·Ecotoxicology and Environmental Safety·Bixia LiBoguang Wang
Oct 17, 2021·International Archives of Occupational and Environmental Health·Zeng-Hong WuHua-Dong Li

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

FlowJo Vx
Pro Plus
Image
CellQuest

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