Atmospheric pressure laser desorption/chemical ionization mass spectrometry: a new ionization method based on existing themes

Rapid Communications in Mass Spectrometry : RCM
Joshua J CoonW W Harrison

Abstract

We have designed and constructed an atmospheric pressure laser desorption/chemical ionization (AP-LD/CI) source that utilizes a laser pulse to desorb intact neutral molecules, followed by chemical ionization via reagent ions produced by a corona discharge. This source employs a heated capillary atmospheric pressure inlet coupled to a quadrupole ion trap mass spectrometer and allows sampling under normal ambient air conditions. Preliminary results demonstrate that this technique provides approximately 150-fold increase in analyte ions compared to the ion population generated by atmospheric pressure infrared matrix-assisted laser desorption/ionization (AP-IR-MALDI).

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Citations

Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Sabine GuentherZoltán Takáts
Nov 3, 2011·Journal of the American Society for Mass Spectrometry·Daiki AsakawaMitsuo Takayama
Apr 5, 2008·Journal of the American Society for Mass Spectrometry·Kaveh JorabchiLloyd M Smith
Jul 29, 2008·Journal of the American Society for Mass Spectrometry·Jason S SampsonDavid C Muddiman
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Mar 15, 2016·Methods : a Companion to Methods in Enzymology·Kermit K MurraySuman Ghorai
Aug 4, 2004·Mass Spectrometry Reviews·Wen-Ping PengHuan-Cheng Chang
Mar 31, 2004·Rapid Communications in Mass Spectrometry : RCM·Kevin Turney, W W Harrison
Apr 3, 2003·Rapid Communications in Mass Spectrometry : RCM·Christine A MillerPatrick D Perkins
Jul 25, 2009·Mass Spectrometry Reviews·Thomas R CoveyBradley B Schneider
Nov 22, 2005·Rapid Communications in Mass Spectrometry : RCM·Jentaie ShieaJan Sunner
Aug 2, 2008·Journal of Mass Spectrometry : JMS·Gary J Van BerkelOlga Ovchinnikova
Jan 30, 2008·The Analyst·Yohannes H RezenomKermit K Murray
Jul 12, 2002·Journal of Mass Spectrometry : JMS
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Jan 25, 2019·Journal of Mass Spectrometry : JMS·Remilekun O LawalKermit K Murray
Jan 9, 2020·Rapid Communications in Mass Spectrometry : RCM·Timotej StrmeňJosef Cvačka
Apr 22, 2008·ACS Chemical Biology·Christen Brownlee
Dec 22, 2009·Analytical Chemistry·Joshua M SymondsThomas M Orlando
Dec 2, 2020·Analytical Chemistry·Ezaz AhmedWilliam A Donald

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