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A/T/N polygenic risk score for cognitive decline in old age

bioRxiv

Nov 12, 2019

Annah M. MooreTimothy J. Hohman

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Abstract

We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid plaques (A), phosphorylated tau tangles (T), and neurodegeneration (N)) framework and compared a PRS based on clinical AD diagnosis to assess which was a better predictor of cognitive decline. We used summary st...read more

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Alzheimer's Disease
Amyloid
Biological Markers
Cerebrospinal Fluid
Composite Resins
Genome
Hippocampus (Brain)
Memory
Nerve Degeneration
Trichomonas vaginalis
23
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A/T/N polygenic risk score for cognitive decline in old age

bioRxiv

Nov 12, 2019

Annah M. MooreTimothy J. Hohman

DOI: 10.1101/838847

Abstract

We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid plaques (A), phosphorylated tau tangles (T), and neurodegeneration (N)) framework and compared a PRS based on clinical AD diagnosis to assess which was a better predictor of cognitive decline. We used summary st...read more

Mentioned in this Paper

Alzheimer's Disease
Amyloid
Biological Markers
Cerebrospinal Fluid
Composite Resins
23

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