A/T/N polygenic risk score for cognitive decline in old age

doi:10.1101/838847

A/T/N polygenic risk score for cognitive decline in old age

bioRxiv

Nov 12, 2019

Annah M. MooreTimothy J. Hohman

DOI: 10.1101/838847

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Abstract

We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid plaques (A), phosphorylated tau tangles (T), and neurodegeneration (N)) framework and compared a PRS based on clinical AD diagnosis to assess which was a better predictor of cognitive decline. We used summary st...read more

Mentioned in this Paper

Alzheimer's Disease

Amyloid

Biological Markers

Cerebrospinal Fluid

Composite Resins

Genome

Hippocampus (Brain)

Memory

Nerve Degeneration

Trichomonas vaginalis

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