Atomic force microscopy characterization of corneocytes: effect of moisturizer on their topology, rigidity, and friction

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
R M GaikwadI Sokolov

Abstract

Atomic force microscopy (AFM) is a novel technique for skin characterization. To develop AFM tests for characterization of the outermost epidermis layer, corneocytes. As an example, the effect of moisturizer on the corneocyte properties is studied. Topology, rigidity, and friction (between individual corneocytes and AFM probe) of the top layer of corneocytes were measured by means of Veeco DM3100 AFM. Quench moisturizing cream was applied daily on the forearm of five volunteers for a period of 9 days. The skin flakes were collected before and after the treatment using Cuderm tape strips. No additional treatment of flakes was performed before the measurements. A protocol for the AFM study of corneocytes is developed. After the treatment, we observed overall smoothening of the corneocyte surface, an increase of friction, and a decrease of rigidity (the Young modulus). AFM can be used as a very sensitive tool for early detection of changes in corneocytes.

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Citations

Dec 24, 2013·International Journal of Pharmaceutics·Martha L Vázquez-GonzálezJordi Hernández-Borrell
Dec 12, 2012·The Journal of Investigative Dermatology·James D BeardSergey N Gordeev
May 16, 2013·The Journal of Investigative Dermatology·Michael J Conneely, Paul A Campbell
Jan 19, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Shuzheng LiIgor Sokolov
Dec 31, 2020·Pharmaceutics·José L SorianoBeatriz Clares

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