Atomic force microscopy: From red blood cells to immunohaematology

Advances in Colloid and Interface Science
Natasha YeowGil Garnier

Abstract

Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.

Citations

Sep 15, 2017·Microscopy Research and Technique·Dinara SobolaLubomír Grmela
Nov 15, 2018·International Journal for Numerical Methods in Biomedical Engineering·Ayse Cetin, Mehmet Sahin
Apr 17, 2019·Journal of Cellular Physiology·Sangwoo KwonKyung Sook Kim
May 11, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jing LiuYongsheng Ding
Jun 19, 2018·Frontiers in Physiology·Rick HuisjesRichard van Wijk
Feb 11, 2020·Frontiers in Physiology·Mallorie DepondPapa Alioune Ndour
Jan 12, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Gábor BaloghEdit Hermesz
Aug 14, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yang YangXinghua Zhang

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