PMID: 9659616Jul 11, 1998Paper

Atomic force microscopy used for the surface characterization of microcapsule immunoisolation devices

Journal of Biomedical Materials Research
K XuT G Wang

Abstract

The surface morphology of the microcapsule used as a bioartificial pancreas was examined by atomic force microscopy (AFM) under ambient conditions in a liquid environment. The standard contact mode was used for imaging. The capsules exhibited different morphologies and surface roughness depending on the composition of the cation solution: namely, the mole ratio of antigelling and gelling cations [Na+]/[Ca2+]. Surface roughness parameters obtained by AFM measurements provide quantitative information on the surface properties of the capsular membrane. In this respect, AFM can be considered a valuable technique complementary to optical microscopy in providing feedback for capsule optimization.

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Citations

Jul 24, 2013·Advanced Drug Delivery Reviews·Anne Mari A RokstadBerit L Strand
Aug 16, 2000·Advanced Drug Delivery Reviews·B Ríhová
Nov 19, 2003·Journal of Biomedical Materials Research. Part a·C M BüngerP de Vos
Jun 5, 2003·Biotechnology and Bioengineering·Feng ShenPatricia L Chang
Jan 19, 2002·Annals of the New York Academy of Sciences·R StorrsH Rilo

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