Atomoxetine administration combined with intensive speech therapy for post-stroke aphasia: evaluation by a novel SPECT method

The International Journal of Neuroscience
Naoki YamadaMasahiro Abo

Abstract

We clarified the safety, feasibility, and efficacy of atomoxetine administration combined with intensive speech therapy (ST) for patients with post-stroke aphasia. In addition, we investigated the effect of atomoxetine treatment on neural activity of surrounding lesioned brain areas. Four adult patients with motor-dominant aphasia and a history of left hemispheric stroke were studied. We have registered on the clinical trials database (ID: JMA-IIA00215). Daily atomoxetine administration of 40 mg was initiated two weeks before admission and raised to 80 mg 1 week before admission. During the subsequent 13-day hospitalization, administration of atomoxetine was raised to 120 mg and daily intensive ST (120 min/day, one-on-one training) was provided. Language function was assessed using the Japanese version of The Western Aphasia Battery (WAB) and the Token test two weeks prior to admission, on the day of admission, and at discharge. At two weeks prior to admission and at discharge, each patient's cortical blood flow was measured using (123)I-IMP-single photon emission computed tomography (SPECT). This protocol was successfully completed by all patients without any adverse effects. Four patients showed improved language function wit...Continue Reading

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Citations

May 5, 2017·Clinical Neuropharmacology·Paul Carrillo-MoraMarlene A Rodríguez-Barragán
Jul 8, 2020·Neuropsychological Rehabilitation·Sam R HarveyMiranda L Rose
Nov 20, 2016·Restorative Neurology and Neuroscience·Andrea WardLumy Sawaki

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