Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity

The Journal of Clinical Psychiatry
Thomas J SpencerJoseph Biederman

Abstract

The objective of this study was to determine if measures of broad clinical psychopathology or neuropsychological performance could aid in the prediction of therapeutic response to the highly selective norepinephrine transporter inhibitor, atomoxetine, among adults with attention-deficit/hyperactivity disorder (ADHD). We analyzed data from 2 double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N = 256) with DSM-IV-defined ADHD who were recruited by referral and advertising. Subjects were randomly assigned to 10 weeks of treatment with atomoxetine or placebo and were assessed with Conners' Adult ADHD Rating Scales (CAARS), the General Well-Being Schedule (GWB), the Sheehan Disability Scale, the Stroop Color-Word Test (SCWT), and the Structured Clinical Interview for DSM-IV (SCID) before and after treatment. Therapeutic improvement on atomoxetine as evidenced by reduced CAARS scores was reliably predicted by the presence of a lifetime comorbid diagnosis of depression or post-traumatic stress disorder at baseline, while improvement on subscales of the GWB and Sheehan Disability Scale were predicted by these and other SCID endorsements, such as alcohol and substance use, as well as...Continue Reading

Citations

Jun 7, 2007·Current Opinion in Psychiatry·Kathleen R Merikangas, Amanda Kalaydjian
Jan 1, 2007·International Journal of Psychiatry in Clinical Practice·Jason LutyOkon Umoh
Oct 16, 2015·The Australian and New Zealand Journal of Psychiatry·Yu-Ju LinSusan Shur-Fen Gau
Nov 29, 2015·Attention Deficit and Hyperactivity Disorders·Azar MohammadzadehNahid Noorian
Aug 24, 2017·BMC Psychiatry·Martin A KatzmanLarry J Klassen
May 24, 2019·Journal of Child and Adolescent Psychopharmacology·Muhammad Umair Khan, Parisa Aslani
Apr 27, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael RöslerBarbara Schäuble
Jul 31, 2012·Current Psychiatry Reports·Aviv Weinstein, Abraham Weizman
Apr 11, 2012·Journal of Developmental and Behavioral Pediatrics : JDBP·Todd P LevineMary B Roberts
Apr 3, 2013·Expert Review of Neurotherapeutics·Glaucia Chiyoko Akutagava-MartinsMara Helena Hutz
Jan 28, 2014·PloS One·Cristina NombelaJames B Rowe
Mar 21, 2015·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Kristin Billaud Feragen, Nicola Marie Stock
Feb 17, 2009·Journal of Developmental and Behavioral Pediatrics : JDBP·Kevin M Antshel, Russell Barkley
Oct 7, 2008·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Stephen V Faraone, Kevin M Antshel
Sep 28, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Thomas GüntherTimo D Vloet
Dec 23, 2016·Therapeutic Advances in Psychopharmacology·Ahmed Naguy
Jun 2, 2011·Journal of Abnormal Child Psychology·Paulo A GrazianoAdam Reid
Jun 29, 2010·Journal of Child and Adolescent Psychopharmacology·Nakia Gray ScottDean Kjar
Dec 12, 2012·Harvard Review of Psychiatry·Jacob L FreedmanMichelle Friedman-Yakoobian
Apr 8, 2015·Journal of Attention Disorders·Adil ZorluYetis Isildar
Oct 10, 2018·Journal of Attention Disorders·Michael J SilversteinLenard A Adler
Dec 2, 2008·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Paula RiggsFrank Vocci
Oct 18, 2007·Expert Review of Neurotherapeutics·Lucy CumynLily Hechtman
Mar 12, 2020·BMC Medical Research Methodology·Hoda ShirafkanMostafa Hoseini
Jan 6, 2021·Child Psychiatry and Human Development·Angela DeottoMaggie E Toplak
Aug 26, 2021·Chemical Research in Toxicology·Yutong YouJiang Zheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.