Atomoxetine once daily for 24 weeks in adults with attention-deficit/hyperactivity disorder (ADHD): impact of treatment on family functioning

Clinical Neuropharmacology
Linda WietechaKeith Saylor

Abstract

To assess the efficacy of atomoxetine (ATX) and impact of treatment on family functioning in adults with ADHD. Adults with attention-deficit/hyperactivity disorder (ADHD) having both a spouse/partner and child were randomized to placebo (n = 234) or ATX (n = 268) for 24 weeks. Attention-deficit/hyperactivity disorder measures included the Conners Adult ADHD Rating Scale total ADHD Symptoms score and Clinical Global Impression-ADHD-Severity. Marital measures included the Dyadic Adjustment Scale and the Family Assessment Measure Dyadic Relationship Scale (FAM III). Parenting measures included the Parenting Stress Index, Alabama Parenting Questionnaire, and Parenting Sense of Competence Scale (PSCS). Improvement was greater with ATX over placebo at 24 weeks on the Conners Adult ADHD Rating Scale (-16.43 vs -8.65; P < 0.001, repeated measures) and Clinical Global Impression (P < 0.001, last observation carried forward). Baseline-to-end point changes in marital and parenting measures were significant but not between treatment groups. Post hoc analyses showed significant interaction of treatment and impairment for the FAM III Task Accomplishment (patient) and Role Performance (patient and spouse) items and PSCS efficacy. Further stra...Continue Reading

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Citations

Jul 1, 2015·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Thomas JansAlexandra Philipsen
Jun 6, 2015·Clinical Psychology Review·David Williamson, Charlotte Johnston
Jun 2, 2015·Developmental Review : DR·AliceAnn CrandallAnne W Riley
Feb 17, 2017·Journal of Attention Disorders·David Williamson, Charlotte Johnston
Dec 4, 2019·Journal of Child and Adolescent Psychopharmacology·Chi-Yung ShangSusan Shur-Fen Gau
Dec 28, 2016·Journal of Abnormal Child Psychology·Andrea Chronis-TuscanoMark A Stein

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