Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder

Postgraduate Medicine
Daniel J WalkerKathleen A Day

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a CNS disorder that has its onset in childhood, but often persists into adulthood. There is growing recognition that adult ADHD can result in multiple negative consequences for individuals. ADHD is also often associated with a number of comorbid psychiatric disorders. Atomoxetine (ATX), a nonstimulant, selective noradrenergic reuptake inhibitor, was approved in the United States in 2002 for the treatment of ADHD in children and adolescents, as well as adults. We review here the safety and efficacy of ATX in adults with ADHD, including data in special populations, functional outcomes, as well as provider and patient real-world perceptions. We searched the databases Embase, MEDLINE and PsycINFO using the terms 'ADHD' and 'adult' and 'ATX' capturing publications from January 1, 1998, to March 27, 2014. Only publications in English were considered. ATX demonstrated significantly greater improvement than placebo (PBO) on the Conners Adult ADHD Rating Scale-Investigator rated:Screening Version (CAARS-Inv:SV) in all trials (N = 6; total score difference ranged from -3.5 to -5.5). For long-term trials using the CAARS-Inv:SV, ATX demonstrated significantly greater improvement than PBO i...Continue Reading

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Citations

May 9, 2016·CNS Drugs·Lucie BarateauYves Dauvilliers
May 22, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Tian LanGuo-Xin Hu
Aug 24, 2016·Current Treatment Options in Neurology·Lucie BarateauYves Dauvilliers
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Oct 23, 2018·Journal of Clinical Psychopharmacology·Carly B WarnerJamie N Brown

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