Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity

Archives of Dermatological Research
James HolmesIan Todd

Abstract

Atopic dermatitis (AD) is a widespread condition that appears to be increasing in prevalence and severity worldwide, yet the underlying mechanisms are not well understood. Recent research has identified various similarities between AD and autoimmune conditions, as well as indicating that there may be an association between AD and autoimmunity. This systematic review evaluates the association between AD and autoimmunity, as well as between severity of disease in AD and autoimmunity, with an emphasis on the associations with autoantibodies. MEDLINE (1946 to December 2017) and Embase (1974 to December 2017) databases were searched. Further relevant articles were retrieved from reference lists. Only studies measuring direct indicators of autoimmunity, in humans, were included. Qualitative analysis was carried out for all studies. In addition, quantitative analysis was used to evaluate prevalence of IgE autoantibodies and anti-nuclear antibodies (ANAs) in AD patients and control subjects. The Mantel-Haenszel method was used with a random-effects model. 28 studies assessed the occurrence of autoantibodies in AD patients and 16 studies were used to evaluate association between disease severity and autoantibodies. Pooled analysis from ...Continue Reading

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Citations

May 9, 2019·JMIR Mental Health·Manuela FerrariSrividya N Iyer
Dec 31, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Enrico ScalaRiccardo Asero
Jul 7, 2020·International Journal of Molecular Medicine·Jia-Long ChenRui-Qun Qi
Jul 12, 2019·Frontiers in Immunology·Claudia ZeidlerSonja Ständer
Aug 11, 2020·Clinical and Translational Allergy·Fariza Mishaal Saiema BadloeInge Kortekaas Krohn
Jul 23, 2021·The Journal of Investigative Dermatology·Kuang-Den ChenHo-Chang Kuo

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