Atopic dermatitis, dry skin and serum IgE in children in a community in japan

International Archives of Allergy and Immunology
Takeshi WakamoriKotaro Ozasa

Abstract

Long-term, prospective studies investigating the prevalence, serum IgE and the natural history of atopic dermatitis (AD) in a community are lacking. In a Japanese community, the skin of primary school children and junior high school students was examined and a questionnaire was given to their parents; their serum total IgE, and house dust mite (HDM)- and Japanese cedar pollen (JCP)-specific IgE levels were also assessed once a year for 9 years. The median AD prevalence in all students (492 in 1998 and 380 in 2004) was 7.6% (6.1-10.4%). The prevalence and the area of skin eruptions of AD decreased with growth. Serum total and HDM-specific IgE levels were high in AD patients, and significant differences were noted for both levels between children with and without later remission of skin eruptions at the time of primary school entry. IgE level increases were noted in the following order: healthy skin < dry skin < AD. In children presenting only with dry skin without atopic disorders, such as AD, asthma and allergic rhinitis, levels of total HDM- and JCP-specific IgE were significantly higher than in children with healthy skin. The infantile IgE level serves as a prognostic index, and sensitization to inhalant allergens may be easi...Continue Reading

Citations

Jul 9, 2009·The Journal of Dermatology·Norito Katoh
Nov 6, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R M AndersenH I Maibach
Jun 15, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chantel NgChun Kwok Wong
Oct 11, 2019·The Journal of Dermatology·Norito KatohKiwako Yamamoto-Hanada

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