Atopic dermatitis: from the genes to skin lesions

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Atopic dermatitis: from the genes to skin lesions

Abstract

References

Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart

Lack of linkage between atopy and locus 11q13

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)

Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI

The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7

IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE

Induction of Fc epsilon R2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and gamma interferon

Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q

Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation

Allergy in atopic dermatitis

Parental smoking, breast feeding, and respiratory infection in development of allergic diseases

Changes in the reported prevalence of childhood eczema since the 1939-45 war

The epidemiology and genetics of atopic allergy

Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy

The incidence of allergy--has it changed?

Langerhans cell phenotyping: a new tool for differential diagnosis of inflammatory skin diseases

Demonstration of the high-affinity IgE receptor on human Langerhans cells in normal and diseased skin

Treatment of severe atopic dermatitis with extracorporeal photopheresis

Cyclosporin in atopic dermatitis: time to relapse and effect of intermittent therapy

Pathogenesis of atopic eczema

Practical management of atopic eczema

Mast cells are one major source of interleukin-4 in atopic dermatitis

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. II. Observer variation of clinical diagnosis and signs of atopic dermatitis

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation

Atopic dermatitis: triggering factors

Chromosome 11q13 and atopy underlying atopic eczema

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes

Atopic dermatitis: recent trends in pathogenesis and therapy

Human keratinocytes release the endogenous beta-galactoside-binding soluble lectin immunoglobulin E (IgE-binding protein) which binds to Langerhans cells where it modulates their binding capacity for IgE glycoforms

Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide

Atopic dermatitis in children: who cares? Who pays?

Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness

Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema

Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis

Association between genetic variants of mast-cell chymase and eczema

Development and validation of diagnostic scores for atopic dermatitis incorporating criteria of data quality and practical usefulness

The expanding universe of T-cell subsets: Th1, Th2 and more

Absence of linkage between 5q markers and serum IgE levels in four large atopic families

The high-affinity receptor for IgE is the predominant IgE-binding structure in lesional skin of atopic dermatitis patients

Genetic studies of atopy and atopic dermatitis

Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin

Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema

Fc epsilon RI-expressing antigen-presenting cells: new players in the atopic game

A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group

Aging and the skin immune system

A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor

Linkage and allelic association of atopy and markers flanking the IL4-receptor gene

Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families

Citations

Outside-inside or inside-outside? Impaired skin barrier as a primary defect in atopic eczema

Lessons from atopy patch testing in atopic dermatitis

Patch testing for noncontact dermatitis: the atopy patch test for food and inhalants

Current aspects of innate and adaptive immunity in atopic dermatitis.

Innate immunity in atopic dermatitis

Viral infections in atopic dermatitis: pathogenic aspects and clinical management

Immune mechanisms leading to atopic dermatitis

Topical immunomodulatory agents and their targets in inflammatory skin diseases

Immune dysregulation in atopic dermatitis

Pathophysiology of atopic dermatitis

Animal models of atopic dermatitis

Mechanisms of food allergy

Urinary eosinophil protein X in children with atopic dermatitis: relation to atopy and disease activity

Epidemiology, clinical features, and immunology of the "intrinsic" (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis)

Increased plasma eotaxin in atopic dermatitis and acute urticaria in infants and children

Natural history of "intrinsic" atopic dermatitis

A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force

Natural course of AEDS

Atopic eczema/dermatitis syndrome - a genetically complex disease. New advances in discovering the genetic contribution

Phenotyping of epidermal dendritic cells allows the differentiation between extrinsic and intrinsic forms of atopic dermatitis

Epidemiology of atopic dermatitis

Putative mechanisms underlying chronicity in atopic eczema

Effects of orally administered Actinidia arguta (Hardy Kiwi) fruit extract on 2-chloro-1,3,5-trinitrobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice

The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 knockout mice

Immunology of diseases associated with Malassezia species.

Eczema in pregnancy