Atopic Dermatitis: Update on Pathogenesis and Therapy

Pediatric Annals
Norma Olivia de la O-Escamilla, Robert Sidbury

Abstract

Atopic dermatitis (AD) is the most common inflammatory skin condition in pediatric patients. AD has long been associated with comorbidities including food allergies, asthma, and allergic rhinitis, but recent literature has expanded this list to include attention-deficit/hyperactivity disorder and depression. AD has tremendous impact on quality of life for both affected children and their families. Improved understanding of AD pathogenesis, particularly regarding skin barrier dysfunction, the role of the cutaneous microbiome, and immune dysregulation, has spawned exciting new therapeutic directions. Although good skin care and appropriate use of topical corticosteroids remain first-line treatment, more precisely targeted treatments hold great promise. A recently approved topical phosphodiesterase inhibitor, crisaborole, and a subcutaneously administered interleukin-4/interleukin-13 blocker, dupilumab, are the first of what will likely be many new treatment options for patients with AD. [Pediatr Ann. 2020;49(3):e140-e146.].

References

Feb 28, 2002·Journal of the American Academy of Dermatology·Charles N EllisKuo B Tong
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Feb 29, 2008·Pediatric Dermatology·Anthony J ManciniSarah L Chamlin
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Aug 27, 2010·The Journal of Investigative Dermatology·Tatyana E ShawEric L Simpson
Jun 19, 2013·Pediatrics·Erin F MathesRichard Antaya
May 13, 2014·Journal of the American Academy of Dermatology·Robert SidburyUNKNOWN American Academy of Dermatology
May 13, 2014·Journal of the American Academy of Dermatology·Lawrence F EichenfieldRobert Sidbury
Nov 26, 2014·Pediatrics·Megha M TollefsonUNKNOWN Section On Dermatology
Feb 19, 2015·JAMA Dermatology·David J MargolisWarren B Bilker
Jun 9, 2016·Pediatric Dermatology·Lynda SchneiderAmy S Paller
Nov 25, 2017·The Journal of Investigative Dermatology·Michael R Williams, Richard L Gallo
Jun 23, 2018·Nature Reviews. Disease Primers·Stephan WeidingerAlan D Irvine
Oct 27, 2018·Journal of the American Academy of Dermatology·Kevin R PatelJonathan I Silverberg
Nov 27, 2018·The Journal of Allergy and Clinical Immunology·Amy S PallerAlan D Irvine
Dec 24, 2018·Expert Review of Clinical Immunology·Kadra KalamahaJonathan Rodrigues
Jan 23, 2019·The Cochrane Database of Systematic Reviews·Uwe MatterneChristian J Apfelbacher
Apr 3, 2019·Current Opinion in Pediatrics·Diana ChernikovaMarcus Shaker
Apr 7, 2019·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Patrick M Brunner
May 16, 2019·Current Opinion in Pediatrics·Diana ChernikovaMarcus Shaker
Jul 19, 2019·Immunological Medicine·Hiraku Suga, Shinichi Sato

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Citations

Oct 4, 2020·Experimental Dermatology·Darya PavlenkoTasuku Akiyama
Dec 22, 2020·Journal of Dietary Supplements·Davide Chesini, Marco Caminati
Feb 3, 2021·Journal of Microbiology and Biotechnology·Minji ParkWon Hee Jung

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