Atopic dermatitis

Current Opinion in Immunology
M A Brown, J M Hanifin

Abstract

AD is a complex, multifactorial, cutaneous manifestation of the atopic diathesis. Observations from bone marrow transplantation cases have shown transmission of the disease from atopic donors [30] and indicate that the basic defect is carried in immune and inflammatory cells which infiltrate skin lesions. Mast cells appear to be important in the initiation of inflammatory events and eosinophils may have an important role in perpetuating the response. New evidence suggests that IL-4 may be a crucial factor controlling mast cells as well as IgE production in allergic disease. The significance of the Fc&RII/CD23 in regulating IgE synthesis and its role in Langerhans' cell/antigen interactions in atopic dermatitis represents an intriguing area in need of further study.

Citations

Mar 10, 1999·Journal of Cutaneous Medicine and Surgery·V S Beltrani
Apr 3, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Katsuo MatsumotoHachiro Tagami
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T MatsuyamaT Nishimura
Jun 10, 2000·The British Journal of Dermatology·R C KiekensC A Bruijnzeel-Koomen
Jul 7, 2005·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Katsuo MatsumotoHachiro Tagami
Jul 27, 2021·Frontiers in Allergy·Erik D AndersonIan A Myles

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