Atopic eczema and allergy

Current Allergy Reports
J RingH Behrendt

Abstract

Although the pathomechanisms of respiratory atopy are well established, the role of IgE-mediated hypersensitivity in the elicitation and maintenance of eczematous skin lesions in atopic eczema (AE) is still controversial. There is, however, evidence for exogenous elicitation of AE by contact with aero- or food allergens (house dust mite, cat, and so forth). Recent investigations show that epidermal Langerhans' cells bind IgE via different receptors, especially the high-affinity receptor (Fc epsilon RI), which is significantly more strongly expressed in lesional skin of AE compared with other inflammatory skin diseases including allergic contact dermatitis. The clinical relevance of IgE-mediated sensitization in AE has been evaluated by the so-called atopy patch test (APT). The APT shows a much higher specificity compared with the skin prick test and radioallergosorbent test. However, allergic reactions do not play a decisive role in every case of AE. Other factors, such as nonspecific skin irritability or psychosomatic interactions, have to be considered. The concept of "extrinsic" versus "intrinsic" types of AE seems attractive. The concept of AE starting with TH2 inflammation, becoming TH1 inflammation in chronicity, and fina...Continue Reading

References

Aug 1, 1992·The Journal of Allergy and Clinical Immunology·F C van ReijsenG C Mudde
May 1, 1992·The Journal of Experimental Medicine·T BieberC de la Salle
Sep 1, 1990·Journal of Dermatological Science·Y TanakaH Yoshida
Jan 1, 1986·Archives of Dermatological Research·C Bruynzeel-KoomenP L Bruynzeel
Feb 1, 1988·The British Journal of Dermatology·C A Bruynzeel-KoomenP L Bruynzeel
Apr 1, 1988·The Journal of Allergy and Clinical Immunology·A D AdinoffR A Clark
Mar 1, 1986·The British Journal of Dermatology·S ReitamoO P Salo
Oct 1, 1986·The British Journal of Dermatology·A GondoY Tokuda
Jan 16, 1982·Lancet·E B MitchellT A Platts-Mills
Jan 1, 1983·The Journal of Allergy and Clinical Immunology·D Y LeungR S Geha
Mar 1, 1995·The Journal of Allergy and Clinical Immunology·U DarsowJ Ring
Oct 1, 1996·The British Journal of Dermatology·M GfesserJ Ring
Mar 21, 1998·The Journal of Allergy and Clinical Immunology·R HirschwehrR Valenta
Mar 17, 2000·The Journal of Allergy and Clinical Immunology·R ValentaG Stingl

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Citations

Jun 6, 2003·The Journal of Investigative Dermatology·Carolyn CharmanHywel Williams
Jun 15, 2007·Regulatory Toxicology and Pharmacology : RTP·Anne Marie ApiWilliam Troy
Nov 6, 2004·The Australasian Journal of Dermatology·Nicholas Aspres, Chris Anderson
May 23, 2006·Clinics in Dermatology·Bernard Naafs
May 20, 2015·Dermatitis : Contact, Atopic, Occupational, Drug·Sharon E JacobRadoslaw Spiewak
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ReiningerS Spitzauer
Jul 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·N GulerU Ones
Jul 9, 2003·Nature Medicine·Yoh-ichi SekiMasato Kubo
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Eva Buentke, Annika Scheynius
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karl J AichbergerRudolf Valenta

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