Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets.

Transfusion
William J SavagePaul M Ness

Abstract

The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients. We identified 37 consecutive apheresis PLT recipients who experienced an ATR and 26 matched controls. Total immunoglobulin (Ig)E and aero- and food allergen-specific IgE were quantified in plasma by a blood test for allergies (ImmunoCAP: Phadiatop and Fx5). IgE testing of apheresis PLT supernatants was also performed. Pruritus and urticaria were manifest in 91.9 and 83.8% of all ATRs, with more severe respiratory symptoms and angioedema occurring in less than 15% of cases. No subject had anaphylaxis. Sex, age, and primary diagnosis were balanced between the two groups. Total and aeroallergen-specific IgE was higher among subjects experiencing an ATR in comparison to control subjects (median total IgE, 55.5 kU/L vs. 8.3 kU/L, p = 0.002; and median aeroallergen-specific IgE, 0.57 kUa/L vs. 0.36 kUa/L, p = 0.046). IgE antibody levels in apheresis products associated with ATRs were similar to control products (p > 0.1 for all IgE tests). Recipient atopic predisposition, as defined by IgE sensitization, is a risk fac...Continue Reading

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Citations

Nov 26, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P Moncharmont, F Meyer
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Majed A Refaai, Neil Blumberg
Apr 17, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P-M Mertes, K Boudjedir
Jan 30, 2013·Transfusion Medicine·D MariotteD Laroche
Jan 12, 2012·Transfusion·Matthew KarafinAaron A R Tobian
Sep 25, 2012·Transfusion·William J SavagePaul M Ness
May 18, 2012·Transfusion·Suchitra Pandey, Girish N Vyas
Dec 3, 2014·Anaesthesia·S HartS A McCluskey
Dec 17, 2019·Transfusion·Andrea M McGonigleParvez M Lokhandwala
Mar 12, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Suryatapa SahaDeepti Sachan
Dec 9, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryu Yanagisawa

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