PMID: 8581840Nov 1, 1995Paper

Atopic status in patients with brittle and non-brittle asthma: a case-control study

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
J F MilesJ G Ayres

Abstract

Sensitization to inhaled and ingested allergens is an important process in determining the subsequent clinical expression of asthma. Allergen exposure has also been reported to be associated with admission to hospital with acute severe asthma. Patients with brittle asthma, characterized by widely variable peak expiratory flow are at increased risk of life-threatening episodes but the role of atopy in these patients is unknown. To determine the atopic status of patients with brittle asthma using a case-control design. We have assessed the atopic status by skin-prick tests to 19 common allergens, and total and specific immunoglobulin E (IgE) in 29 patients with well characterized brittle asthma and an age, sex and treatment-matched control group without brittle asthma. Mean weal diameters were higher in brittle compared to non-brittle asthma for grass pollen (4.64 vs 2.17; P = 0.01), horse hair (6.28 vs 2.64; P = 0.02), feathers (2.96 vs 1.52; P = 0.01), wheat (1.48 vs 0.66; P = 0.001) and chocolate (1.09 vs 0.41; P = 0.05). Mean radioallergosorbent (RAST) scores to house dust mite were also greater in brittle asthma patients (19.3 vs 7.65; P = 0.05). Patients with brittle asthma also exhibited a significantly greater degree of a...Continue Reading

Citations

Jul 27, 2011·Current Allergy and Asthma Reports·Ritesh Agarwal
Jun 30, 2004·Paediatric Respiratory Reviews·Jon G AyresTitus Ninan
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y I KohH Lim
Sep 19, 1998·Thorax·J G AyresP J Barnes
Feb 22, 2005·BMC Pulmonary Medicine·B Ronan O'DriscollDavid W Denning
Jul 29, 2010·Medical Mycology·Ritesh Agarwal, Dheeraj Gupta
Dec 27, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Sarah K MedrekAmit D Parulekar
Jun 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Gillman, Jo A Douglass
Mar 8, 2003·Allergy·G GarciaM Humbert
Sep 6, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Christina D SchwindtRalph J Delfino
May 25, 2011·Mycoses·Ritesh AgarwalArunaloke Chakrabarti
Apr 21, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D Gibeon, K F Chung
Oct 29, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J SalamzadehH Chrystyn
Apr 5, 2001·Journal of the Royal Society of Medicine·J Ayres

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