PMID: 11332297May 3, 2001Paper

Atopic status of an adult population with active and inactive tuberculosis

Allergy and Asthma Proceedings
D MunganZ Misirligil

Abstract

The rise in allergic disorders over the past three decades has been suggested to be related to the decrease in infectious diseases. Recently, a negative association between tuberculin responses and atopic disorders has also been reported. We planned to investigate the effect of natural exposure to Mycobacterium tuberculosis on atopic status in patients with active tuberculosis and to compare the findings with the data of patients with inactive disease. A total of 97 subjects were divided into two groups. Group 1, patients with proven active pulmonary tuberculosis (n = 66); group 2, subjects who had a history of previous tuberculous disease, with negative bacteriologic studies and no clinical and/or roentgenographic evidence of current disease (n = 31). Current history of allergic diseases was recorded by a physician with the use of a questionnaire adapted from the European Community Respiratory Health Survey (ECRHS), and skin-prick tests (SPTs) were performed using a standardized panel. Total IgE and Phadiatop were measured by the Pharmacia uniCAP system. The rate of one or more positive SPTs was significantly lower in the patients with active tuberculosis than the inactive group (15% versus 48.4%, p < 0.001). The current histo...Continue Reading

Citations

Jun 30, 2009·BMC Infectious Diseases·Linda K EllertsenGeir Hetland
Dec 22, 2006·Expert Review of Vaccines·Manuel Sánchez-Solis, Luis García-Marcos
Feb 13, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ahmet SoysalMustafa Bakir
Jan 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Manami RyozawaSusumu Furukawa
Mar 28, 2007·Scandinavian Journal of Immunology·A KutluE Bozkanat
Feb 14, 2006·Respiratory Medicine·F Y AnlarR Karşi
Oct 8, 2005·International Archives of Allergy and Immunology·L K EllertsenG Hetland

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