Atopy and nonspecific bronchial responsiveness. A population-based assessment. Spanish Group of the European Community Respiratory Health Survey

American Journal of Respiratory and Critical Care Medicine
J B SorianoJ M Antó

Abstract

The relative importance of specific immunoresponse in explaining nonspecific bronchial responsiveness (BR) has scarcely been examined. We provide quantitative estimates of the proportion of BR attributable to specific atopy to different common aeroallergens. We used data from a cross-sectional study on a random sample of the general population 20 to 44 yr of age from five Spanish areas. There were 1,816 participants who performed a methacholine challenge and had atopy assessed. BR was defined as a 20% or more fall in FEV1. Atopy was assessed by measuring serum-specific IgE or skin tests to cat, Dermatophagoides pteronyssinus, Cladosporium, Alternaria, timothy grass, olive, birch, Parietaria, or ragweed. The strongest associations between BR and specific IgE response were against timothy grass (prevalence rate ratio = 1.78; 95% confidence interval 1.2 to 2.6), Dermatophagoides pteronyssinus = 1.64 (1.2 to 2.2), and olive = 2.36 (1.5 to 3.7), all after adjustment by age, sex, area of residence, smoking, and a positive response to any of the other eight allergens measured. The population attributable risk of BR for a positive response to any of the nine allergens measured was 20.96% (10.2 to 43.2%) when adjusting for area of resid...Continue Reading

Citations

Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Y KornizkyS Kivity
Oct 29, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Y ObaseS Kohno
Jan 30, 2007·Archivos de bronconeumología·Ferran MorellJaume Ferrer
Sep 13, 2002·Chest·Joel SchwartzUrsula Ackermann-Liebrich
Mar 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D CaillaudI Annesi-Maesano

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