Atopy-Dependent and Independent Immune Responses in the Heightened Severity of Atopics to Respiratory Viral Infections: Rat Model Studies

Frontiers in Immunology
Jean-François Lauzon-JosetDeborah H Strickland

Abstract

Allergic (Th2high immunophenotype) asthmatics have a heightened susceptibility to common respiratory viral infections such as human rhinovirus. Evidence suggests that the innate interferon response is deficient in asthmatic/atopic individuals, while other studies show no differences in antiviral response pathways. Unsensitized and OVA-sensitized/challenged Th2high (BN rats) and Th2low immunophenotype (PVG rats) animals were inoculated intranasally with attenuated mengovirus (vMC0). Sensitized animals were exposed/unexposed during the acute viral response phase. Cellular and transcriptomic profiling was performed on bronchoalveolar lavage cells. In unsensitized PVG rats, vMC0 elicits a prototypical antiviral response (neutrophilic airways inflammation, upregulation of Th1/type I interferon-related pathways). In contrast, response to infection in the Th2high BN rats was associated with a radically altered intrinsic host response to respiratory viral infection, characterized by macrophage influx/Th2-associated pathways. In sensitized animals, response to virus infection alone was not altered compared to unsensitized animals. However, allergen exposure of sensitized animals during viral infection unleashes a notably exaggerated air...Continue Reading

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Citations

Jul 13, 2021·Clinical & Translational Immunology·Jean-Francois Lauzon-JosetDeborah H Strickland

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Datasets Mentioned

BETA
GSE98152

Methods Mentioned

BETA
transgenic
FCS
PCR
chip
bronchoalveolar lavage

Software Mentioned

Ingenuity Systems software
LIMMA
ragene21strnentrezgcdf
Ingenuity
ArrayQualityMetrics
R
GraphPad Prism

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